大青叶中4(3H)喹唑酮体外抗H1N1型流感病毒的作用研究  

Effects of 4(3H)quinazolinone from Isatis indigotica leaves against Influenza virus A in vitro

作　　者：许涛[1] 梁剑平[2] 余四九[1] 蒲秀英[1] 王学红[2] 

机构地区：[1]甘肃农业大学动物医学院,甘肃兰州730070 [2]中国农业科学院兰州畜牧与兽药研究所

出　　处：《中兽医医药杂志》2008年第3期7-9,共3页Journal of Traditional Chinese Veterinary Medicine

基　　金：国家攻关项目(2004BA519A26)

摘　　要：目的:探讨大青叶中4(3H)喹唑酮体外抗H1N1型流感病毒的作用。方法:用MTT染色法测定大青叶中4(3H)喹唑酮通过不同加药方式对H1N1型流感病毒的体外抑制作用。结果:大青叶中4(3H)喹唑酮对H1N1型流感病毒具有明显的阻断作用和对细胞内病毒有抑制作用。结论:大青叶中4(3H)喹唑酮具有明显的体外阻止H1N1型流感病毒吸附到靶细胞和抑制H1N1型流感病毒增殖的作用。Objective：To discuss the anti-viral efeets of 4（3H）quinazolinone from Isatis indigotica leaves against influenza virus A in ritro,Methods：The inhibition effeets of 4（3H）quinazolinone against influenza virus A by different drug-added ways in vitro were assayed by MTT staining method.Results：4（3H）quinazolinone from leaves of Isatis indigotica showed an obvious prevention and treatment effects on influenza virus A in vitro by inhibiting viral proliferation and adsorbing to target cells.

关 键 词：大青叶 4(3H)喹唑酮 H1N1型流感病毒 

分 类 号：S853.74[农业科学—临床兽医学]