Relationship between electroacupuncture analgesia and dopamine receptors in nucleus accumbens  

作　　者：王彦青[1] 曹小定[1] 吴根诚[1] 

机构地区：[1]上海医科大学神经生物学教研室

出　　处：《中国药理学报》1997年第6期494-496,共3页Acta Pharmacologica Sinica

摘　　要：目的：研究多巴胺受体拮抗剂左旋四氢巴马汀（ｌＴＨＰ）加强电针镇痛（ＥＡＡ）的原理，阐明中枢神经系统内多巴胺（ＤＡ）系统在ＥＡＡ中的作用．方法：分别将Ｄ１受体激动剂ＳＫ＆Ｆ３８３９３和Ｄ２受体激动剂ｑｕｉｎｐｉｒｏｌｅｈｙｄｒｏｃｈｌｏｒｉｄｅ（Ｑｕｉ）注射入大鼠伏膈核，观察对ＥＡＡ及ｌＴＨＰ加强ＥＡＡ的作用．结果：ＳＫ＆Ｆ３８３９３（５μｇ，１０μｇ）明显对抗了ｌＴＨＰ加强ＥＡＡ的作用，１０μｇＳＫ＆Ｆ３８３９３则减弱ＥＡＡ；Ｑｕｉ（１０μｇ，２０μｇ），对ＥＡＡ及ｌＴＨＰ加强ＥＡＡ的作用没有显著影响．结论：伏膈核内Ｄ１受体活动在ＥＡＡ及ｌＴＨＰ加强ＥＡＡ中起重要作用，Ｄ２受体没有显著作用．IM: To study the roles of dopamine (DA) D 1 and D 2 receptors in nucleus accumbens in electro-acupuncture analgesia (EAA) and the potentiation of EAA of rats induced by l tetrahydropalmatine ( l THP), a dopamine receptor antagonist. METHODS: SK&F 38393 and quinpirole hydrochloride (Qui), highly selective agonists of D 1 and D 2 receptors, respectively were injected into nucleus accumbens of rats. RESULTS: SK&F 38393 (5 and 10 μg) attenuated the potentiation of EAA induced by l THP, 10 μg SKF38393 attenuated EAA as well, while Qui (10 and 20 μg) had no effect on EAA and the potentiation of EAA induced by l THP. CONCLUSION : D 1 but not D 2 receptor in nucleus accumbens play an important role in EAA and the potentiation of EAA induced by l THP.

关 键 词：电针镇痛 伏膈核 多巴胺 受体 

分 类 号：R246.2[医药卫生—针灸推拿学]