普罗帕酮对麻醉兔左心室后负荷变化引起的电生理改变的影响  

Effects of propafenone on electrophysiologic changes caused by alteration of left ventricular afterload in anesthetized rabbits

作　　者：邱汉婴 李迪俊 毛焕元 

机构地区：[1]汕头医科大学附属二院心血管疾病研究室 [2]同济医科大学心血管疾病研究所

出　　处：《中国药理学报》1997年第6期532-534,共3页Acta Pharmacologica Sinica

摘　　要：目的：探讨普罗帕酮（Ｐｒｏ）对兔左心室后负荷变化引起的心室电生理改变的作用．方法：Ｐｒｏ３ｍｇ·ｋｇ－１ｉｖ前后，改变左心室后负荷，观察室性心律失常发生情况；并测定左心室舒张阈值（ＶＤＴ），相对不应期（ＲＲＰ），有效不应期（ＥＲＰ）及其不应期离散和心室纤颤阈（ＶＦＴ）．结果：增加左心室后负荷（Ｂ级），可使左室ＲＲＰ和ＥＲＰ时间离散增加，ＶＦＴ降低，并出现室性心律失常．Ｐｒｏｉｖ后，ＶＤＴ，ＲＲＰ，ＥＲＰ，ＶＦＴ均较用药前显著延长或升高（Ｐ＜００１）；改变左室后负荷，心室电生理参数无显著改变（Ｐ＞００５）．结论：Ｐｒｏ可抑制左室后负荷增加引起的不应期离散增大和ＶＦＴ降低，起到抗室性心律失常的作用．AIM: To study effects of propafenone (Pro) on ventricular electrophysiologic changes caused by alteration of left ventricular afterload of rabbit heart. METHODS: Before and after iv Pro 3 mg·kg -1 , changing afterload of left ventricle (LV), occurrence of ventricular arrhythmia, left ventricular diastolic thresholds (VDT), relative refractory period (RRP), effective refractory period (ERP), dispersion of refractory period, and ventricular fibrillation threshold (VFT) were recorded. RESULTS: Increasing afterload of LV increased temporal dispersion of RRP and ERP [from 11±4 and 6±3 ms to 18±8 and 13±8 ms (+ΔP=8 4±2 9 kPa) individually ( P <0 05)] and decreased VFT [from 5 5±1 0 V to 3 9±0 9 V ( P <0 01)]; Ventricular arrhythmia was seen in all rabbits. But reducing left ventricular afterload did not alter the electrophysiologic parameters in LV and did not induce ventricular arrhythmia. Pro iv prolonged RRP and ERP, increased VDT and VFT( P <0 01); Increasing or decreasing left ventricular afterload did not cause much alteration of ventricular electrophysiologic parameters ( P >0 05). CONCLUSION: Pro inhibited increase of dispersion of refractory period and decrease of VFT caused by increase of left ventricular afterload and has an effect of anti ventricular arrhythmia.

关 键 词：左室功能障碍 心律失常 电生理学 普罗帕酮 

分 类 号：R541.705[医药卫生—心血管疾病] R972.2[医药卫生—内科学]