血清降钙素原监测在新生儿严重感染的临床意义  

Clinical significance of procalcitonin in neonate with severe infection

作　　者：伍剑[1] 唐延松[1] 罗康玲[1] 魏祥松[2] 廖兵[2] 

机构地区：[1]重庆市第九人民医院新生儿科,400700 [2]重庆市第九人民医院检验科,400700

出　　处：《重庆医学》2008年第11期1215-1216,1243,共3页Chongqing medicine

摘　　要：目的探讨血清降钙素原(procalcitonin,PCT)在早期诊断新生儿严重细菌感染性疾病中的临床意义。方法将本院新生儿科的67例新生儿分为重症感染、局部感染和非感染组,进行PCT测定,并与C-反应蛋白(C-reactive protein,CRP)和白细胞记数(WBC)进行比较。结果以PCT≥0.5ng/mL为阳性,重症感染组PCT阳性率(88.46%)与局部感染(38.10%)和非感染组(15.00%)比较差异均有统计学意义(P<0.01),重症感染组CRP阳性率与另两组比较差异均有统计学意义(P<0.01),而WBC在3组间比较差异无统计学意义,PCT与CRP及WBC相比,PCT诊断重症感染的敏感性、阳性预测值、阴性预测值、约登指数最高。结论PCT可作为新生儿重症细菌感染早期诊断的标志物。Objective To investigate the clinical significance of procalcitonin（PCT） in the early diagnosis of severe neonatal in- fections. Methods PCT was measured for 67 neonates in the neonatal department of our hospital, then compared with C-reactive protein （CRP） and WBC. According to the results, the 67 neonates were divided into severe infection group,local-infection and non- infection group. Results If plasma PCT≥0.5ng/mL was taken as positive, the positive rates in severe infection,local-infection, non-infection group were 88.460%, 38.10 %, 15.00% respectively. The positive rate of severe infection group was significantly higher than that of the other 2 groups（P〈0.01） ,also the difference was found in CRP positive rate（P〈0.01） ,but not in WBC count. The diagnostic sensitivity, Youden＇s index, positive and negative predictive value of PCT in severe infection disease were higher than those of CRP and WBC. Conclusion PCT may be the high sensitive and specific marker in the early diagnosis of severe neonatal infections.

关 键 词：降钙素原 感染 新生儿 

分 类 号：R722.1[医药卫生—儿科]