克癌新对荷瘤小鼠IL-2、IL-6、IL-12和TNF-α水平的影响  

Effects of Keaixin (克癌新) on the level of IL-2、IL-6、IL-12 and TNF-α in tumor-bearing mice

作　　者：肖顺汉[1] 刘明华[1] 钟琳[1] 任美萍[1] 黄兴武[1] 田吉[2] 

机构地区：[1]泸州医学院药理学教研室,泸州646000 [2]泸州医学院药物研究所,泸州646000

出　　处：《中药药理与临床》2008年第2期82-84,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：四川省教育厅重点项目(No2005A065)

摘　　要：目的:研究克癌新对荷瘤小鼠细胞因子水平的影响。方法:建立小鼠肉瘤S180和小鼠肝癌H22移植性肿瘤模型,采用Elisa法测定细胞因子白介素-2(IL-2)、白介素-6(IL-6)、白介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)的水平。结果:克癌新在150、300mg/kg时对小鼠肉瘤S180的生长抑制率分别为38.52%、47.88%,对肝癌H22生长抑制率分别为32.17%、40.18%,且能提高荷瘤小鼠的脾指数和胸腺指数;克癌新能升高荷瘤小鼠细胞因子IL-2、IL-6、IL-12、TNF-α的水平。结论:克癌新有体内抗肿瘤活性,其抗肿瘤机制可能与升高机体细胞因子水平有关。Objective：To study the effects of Keaixin on the level of cytokine in tumor-bearing mice. Methods： The inhibitory effect of Keaixin on tumor growth was observed by the models of implanted sarcoma 180 （S180） and hepatoma 22 （H22） in mice. The levels of TNF-α,IL-2,IL- 6 and IL-12 in tumor-bearing mice was investigated by Elisa assay. Result： At dosage of 150 and 300mg/kg, the inhibitory rate of Keaixin is 38.52% and 47.88% for S180, 32.17% and 40.18% for H22, respectively. Keaixin can increase spleen index and thymus gland index, and enhance the expression levels of TNF-α,IL-2 ,IL-6 and IL-12. Conclusion ： Keaixin exhibited significantly anti-tumor effect in vivo and the mechanism may be related to enhancing the level of cytokine.

关 键 词：克癌新 S180 H22 细胞因子 

分 类 号：R285[医药卫生—中药学]