桂枝茯苓软胶囊治疗痛经的实验研究  

Guizhi Fuling Soft Capsule in the Treatment of Dysmenorrhea

作　　者：李莉[1] 孙聪[1] 谷仿丽[2] 王小燕[2] 陈光亮[1] 

机构地区：[1]安徽中医学院中西医结合临床学院,安徽合肥230038 [2]安徽省现代中药研究中心

出　　处：《安徽中医学院学报》2008年第3期35-38,共4页Journal of Anhui Traditional Chinese Medical College

摘　　要：目的:研究桂枝茯苓软胶囊对实验性痛经的影响。方法:缩宫素2.0,0.2u/只腹腔注射分别诱发大鼠、小鼠痛经模型;100g/L蛋清和二甲苯分别诱导大鼠、小鼠急性炎性反应模型;热刺激、冰醋酸诱导小鼠疼痛反应模型。结果:桂枝茯苓软胶囊4.32,2.16,1.08g/kg(大鼠)及8.64,4.32,2.16g/kg(小鼠)灌胃给药,能显著抑制缩宫素所致的大鼠、小鼠扭体反应次数,减少痛经大鼠子宫中PGF2α水平;抑制100g/L蛋清所致的大鼠足肿胀和二甲苯所致小鼠耳肿胀;减少冰醋酸刺激引起的小鼠扭体反应次数;对热刺激引起的小鼠疼痛反应无明显影响。结论:桂枝茯苓软胶囊灌胃给药能抑制缩宫素诱导的动物痛经反应,有明显抗炎和镇痛作用,抑制子宫PGF2α释放可能是其作用机制之一。Objective： To observe the effects of Guizhi Fuling（GF） Soft Capsule on experimental dysmenorrhea. Methods： Oxytocin 2.0,0.2 units per ease was administered by peritoneal injection to induce the reaction of dysmenorrhea in rats and mice, respectively; albumen 100 g/L and dimethybenzene was employed to induce acute inflammtory reaction in rats and mice, respectively; and pain reaction was induced by heat stimulation and acetic acid in mice. Results： GF Soft Capsule 4.32,2. 16,1.08 g/kg（for rats）, and 8.64,4.32,2. 16 g/kg（for mice）remarkably decreased the number and frequency of writhing response of rats and mice; reduced the level of prostaglandin F2a （PGF2a） in uterus of dysmenorrhea rats; inhibited the swelling of ears induced by 100 g/L albumen or dimethylbenzene; decreased the frequency of mouse writhing response induced by acetic acid;and did not impact the mouse pain reaction induced by heat stimulation. Conclusion： GF Soft Capsule could significantly inhibit the experimental dysmenorrhea reaction induced by oxytocin, had significant anti-inflammatory and analgesia action. The mechanism might be related with inhibitive effects of GF extracts on synthesis of PGF2a in uterus.

关 键 词：痛经 桂枝茯苓软胶带 缩宫素 PGF2a 炎症 

分 类 号：R285.5[医药卫生—中药学] R711.51[医药卫生—中医学]