热作用致人前列腺增生组织的光穿透深度变化  

Thermal change on optical penetration depth in human prostatic hyperplasia tissue in vitro

作　　者：魏华江[1] 邢达[1] 何博华[2] 吴荣海[3] 谷怀民[1] 巫国勇[4] 陈雪梅[5] 

机构地区：[1]华南师范大学激光生命科学研究所激光生命科学教育部重点实验室,广州510631 [2]广东药学院临床医学系外科,广州510224 [3]广东省江门市中心医院泌尿外科,江门529071 [4]中山大学第一附属医院外科,广州510080 [5]中山大学第一附属医院眼科,广州510080

出　　处：《激光技术》2008年第3期244-247,共4页Laser Technology

基　　金：国家自然科学基金面上资助项目(6037804330470494);广东省自然科学基金资助项目(01501204010394);广东省科技计划资助项目(2004B10401011)

摘　　要：为了研究热作用下人良性前列腺增生（BPH）组织对532nm，670nm，830nm和1064nm的光穿透深度的变化及其差异。采用了双积分球测量系统以及反向倍增法获取组织的光学特性。得到的实验结果为：在20℃-80℃的温度范围内，BPH组织对532nm，670nm，830nm和1064nm的光穿透深度都是随着激光波长的增大而增大，随着热作用温度的变化而改变的。随着热作用温度的升高，BPH组织对1064nm的光穿透深度的变化显著地较其对532nm，670nm，830nm的光穿透深度的变化都要大得多。其对532nm，670nm，830nm和1064nm的光穿透深度的最大值分别在50℃，50℃，50℃和70℃，其值分别为0．404mm，0．539mm，0．699mm和5．917mm；最小值分别在20℃，20℃，80℃和60℃，其值分别为0．251mm，0，449mm，0．621mm和1．542mm。该测量结果可为激光的光热治疗BPH提供一点有益的参考。Thermal change and its difference on the optical penetration depth of human benign prostatic hyperplasia （BPH） tissue was measured with a double-integrating-sphere setup at 532nm,670nm,830nm and 1064nm The optical properties of BPH tissue were assessed from the measurement results using the inverse adding-doubling method. The results of measurement showed that,in exposure temperature range from 20℃ to 80℃ ,the optical penetration depth of BPH tissue at 532nm,670nm,830nm and 1064nm increased with increase of wavelengths,the optical penetration depth of BPH tissue at 532nm,670nm,830nm and 1064nm varied with a change of exposure temperature by thermal effect,change of the optical penetration depth of BPH tissue at 1064nm was significantly bigger than that of BPH tissues at 532nm,670nm and 830nm,respectively with increase of exposure temperature. Maximal optical penetration depths of BPH tissue at 532nm,670nm,830nm and 1064nm were respectively 0. 404mm,0. 539mm, 0.699mm and 5. 917mm at exposure temperature of 50℃, 50℃ ,50℃ and 70℃, respectively, andminimal optical penetration depths were respectively 0. 251mm,0.449mm,0.621mm and 1. 542mm at exposure temperature of 20℃ ,20℃ ,80℃ and 60℃. The results of measurement indicated a few useful reference data for treatment of BPH using optical and thermal properties of laser.

关 键 词：医用光学与生物技术 组织光学 积分球 人良性前列腺增生组织 激光 光穿透深度 

分 类 号：Q631[生物学—生物物理学] R318.51[医药卫生—生物医学工程]