体温致壳聚糖智能水凝胶  

Chitosan-Based Hydrogel Forming at Body Temperature

作　　者：韦少慧[1] 刘波[1] 吕维忠[1] 张小虎[1] 龙俊杰[1] 吴奕光[1] 

机构地区：[1]深圳大学化学与化工学院,广东深圳518060

出　　处：《稀有金属材料与工程》2008年第A02期723-725,共3页Rare Metal Materials and Engineering

基　　金：深圳大学科研基金资助项目(20020222);深圳市阳光之路生物材料科技有限公司资助项目(WYGA)

摘　　要：将壳聚糖分别溶于盐酸和乙酸水溶液,与不同比例的甘油磷酸酯二钠盐(GPDS)复配,并通过旋转粘度计测量匀速升温条件下复配溶液粘度的变化确定其凝胶化转变温度和时间;差示扫描量热法测定体温致壳聚糖凝胶化转变的温度和热量。结果表明:此系列复配溶液的粘度随温度升高均增加,并出现粘度曲线向上的拐点,对应的温度即其凝胶化转变温度,凝胶化转变温度随GPDS用量增加而降低。其中:溶于100mL乙酸水溶液的复配溶液,升温速率为0.8℃/min,当壳聚糖与GPDS质量比为2.7g:6.0g时,凝胶化转变温度为42℃,达到凝胶化转变温度的时间约25min;溶于100mL盐酸水溶液的复配溶液,升温速率为0.5℃/min,当壳聚糖与GPDS质量比为2.0g:6.0g时,凝胶化转变温度接近体温37℃,达到凝胶化转变温度的时间约24min。差示扫描量热法未观察到此体温致壳聚糖凝胶化转变的热量。Chitosan was dissolved in HCl or HAc solution separately, and mixed with different weight of glycerophosphate disodium salt （GPDS）. The viscosity values of these mixed solutions at equably elevated temperature were recorded, and the DSC curve of that mixed solution forming hydro gel at body temperature was obtained. The research results indicate that the viscosity of these mixed solutions increased as the temperature increased, and the rate enlarged suddenly at a given temperature which is the gelating temperature of this solution. The gelating temperature of these mixed solutions lowered as the weight of GPDS increased. If 2.7 g of chitosan and 6.0 g of GPDS were dissolved in 100 mL of HAc solution and this mixed solution was heated at 0.8 ℃/min, the gelating temperature of this mixed solution reached 42 ℃ in about 25 min. If2.0 g of chitosan and 6.0 g of GPDS were dissolved in 100 mL of HC1 solution and this mixed solution was heated at 0.5 ℃/min, the gelating temperature of this mixed solution reached 37 ℃ （body temperature） in about 24 min. The DSC result indicates that no exothermal or endothermal fluctuation was observed during the formation of chitosan hydrogel.

关 键 词：壳聚糖 甘油磷酸酯二钠盐 粘度 差示扫描量热法 温致水凝胶 

分 类 号：O648.16[理学—物理化学]