细辛的长期毒性研究——长期大量服用细辛对大鼠肝组织形态学及功能的影响  

Research on Long-term Toxicity of Asarum——Effect of Asarum's Long-term Toxicity on Morphology and Function in SD Rat's Liver

作　　者：李晶晶[1] 杨伟峰[1] 周祯祥[1] 廖广辉[1] 陈泽斌[1] 胡平[1] 蔡青[1] 汪琼[1] 

机构地区：[1]湖北中医学院,湖北武汉430065

出　　处：《湖北中医学院学报》2008年第1期5-7,共3页Journal of Hubei College of Traditional Chinese Medicine

摘　　要：目的观察细辛长期毒性对SD大鼠肝组织形态学及功能的影响。方法将120只SD大鼠称重标记,随机分为细辛低剂量组、细辛中剂量组、细辛高剂量组和正常对照组各30只,各给药组依次按0.18、0.95、1.72g/(kg.d)剂量灌胃;对照组给以等体积(3ml)双重蒸馏水,每日1次,各组连续给药4周,停药后继续观察2周。结果长期大量服用细辛可轻度影响大鼠的饮食和体重,表现为饮食减少和体重减轻,但停药后即可恢复;对肝组织形态学及肝功能均有影响,以细辛高剂量组为甚:ALT高于对照组(P<0.05),TBIL明显高于对照组(P<0.01),且给药期与恢复期比较有明显差异(P<0.05)。结论细辛长期毒性对SD大鼠肝组织形态学的影响主要表现为急性肝炎样损伤,导致肝细胞膜通透性增加,甚至坏死,且能影响肝脏对胆红素的摄取、结合和排泄功能,但不会产生延迟性毒性反应。Objectve： To observe the long - term toxicity of Asarum on the morphology and function of rat＇s liver. Method： 120 SD rats are randomly divided into 4 groups including low dosage, middle dosage, high dosage of Asarum and normal control group, and each group has30 rats. Following the dosage of 0. 18, 0. 95, 1. 72g/ （kg · d）, Asarum liquid is orally administed to the medicine groups. The normal control group is orally administed once by the same volume of distilled water everyday. The groups are continuously administed for 4 weeks. After that, rats are still observed for 2 weeks. . Results： The diet and weight of rats are lightly reduced after a long time of Asarum administration. But the damage could be reversible after the medicine is stopped; Asarum has influence on the liver morphology and function, especially the high dosage group： ALT of high dosage group is obviously higher than normal control group （ P 〈 0. 05 ）, TBIL of high dosage group is obviously higher than normal control group （P〈0. 01）, and compared to the medicine -feeding period , ALT, TBIL of high dosage group in the convalecent period are obviously low （ P 〈 0. 05 ） . Conclusiorls： The long - term usage of Asarum may lead to the acute hepatitis injury, the increasing of the liver cell membrane permeability, even the nocrosis of liver cell. It may affect liver＇s absorption, coalescence and drainage of the bilirubin, It may not lead to the delayed toxic effect on the liver.

关 键 词：细辛 肝组织形态学 肝功能 长期毒性试验 

分 类 号：R285.5[医药卫生—中药学]