三七总皂甙对脑缺血再灌注损伤大鼠ICAM-1表达的影响  

Effect of Panax Notoginseng Saponinsa on the expression of ICAM-1 in Rats with Cerebral Ischemia Reperfusion Injury

作　　者：蒋莉萍[1] 曾祥发[2] 陆晖[2] JIANG Li-ping, ZENG Xiang-fa, LU Hui , Guilin（541004）

机构地区：[1]广西桂林医学院基础医学院,桂林541004 [2]广西瑞康医院神经内科,530001

出　　处：《中外健康文摘：医药月刊》2008年第5期45-47,共3页

摘　　要：目的观察三七总皂甙（PNS）对脑缺血再灌注损伤大鼠细胞间粘附分子1（ICAM-1）表达的影响。方法采用线栓法制备大鼠大脑中动脉阻断局灶性脑缺血模型，于脑缺血再灌注24h后断头取脑，用免疫组织化学法检测脑组织中ICAM-1表达，苏木精-伊红染色对脑组织进行病理学检查，光镜下观察脑血管周围白细胞的粘附与渗出。结果PNS能明显抑制大脑皮质及尾壳核ICAM-1的表达，减轻白细胞的粘附与浸润。结论PNS对脑缺血再灌注后的炎性损伤的保护作用可能与抑制ICAM-1表达，减轻白细胞的粘附与浸润有关。Objective： To study effect of Panax Notoginseng Saponinsa（PNS） on the expression of intercellular adhesion molecule-1（ICAM-1） in Rats with Cerebral Ischemia Reperfusion Injury. Methods： The model of local cerebral ischemia-reperfusion was prepared by the intravascular thread occlusion of the middle cerebral arteries（MCAO）. The middle cerebral arteries of rats were occluded for 2 hours and reperfused for 24 hours. The expression of ICAM-1 was observed by immunohistochemical staining. The adhesiveness and infiltration of leucocytes were observed by HE staining. Results： PNS was shown to markedly inhibit the expression of ICAM-1, alleviated the adhesiveness and infiltration of leucocytes. Conclusion： PNShas protective effects on inflammatory injury following Cerebral Ischemia Reperfusion Injury in Rat by inhibiting ICAM-1 expression, alleviating the adhesiveness and infiltration of leucocytes.

关 键 词：三七总皂甙 脑缺血再灌注损伤 细胞间粘附分子1 

分 类 号：R969[医药卫生—药理学;医药卫生—药学]