肺心病患者血浆内皮素-1变化及与其它指标的关系  

CHANGES OF PLASMA ET 1 AND RELATIONSHIP BETWEEN ET 1 AND OTHER INDEXES IN PATIENTS WITH CHRONIC COR PULMONALE

作　　者：刘卓拉[1] 冀锐锋[1] 薄建萍 宋满景 

机构地区：[1]山西医科大学第二医院

出　　处：《山西医药杂志》1997年第5期389-390,共2页Shanxi Medical Journal

基　　金：山西省科委基金

摘　　要：应用ＲＩＡ技术测定了４５例肺心病急性发作期患者的血浆内皮素－１（ＥＴ－１）水平，并用多元线性回归与相关分析ＥＴ－１与患者年龄、血钾、钠、氯离子、肌酐、尿素氮、二氧化碳结合率、尿蛋白及病情轻、中、重的关系。结果显示肺心病患者的ＥＴ－１明显高于正常对照组（Ｐ＜０．０１），且随病情加重而增加；ＥＴ－１与血钾、钠离子及病情严重程度相关（Ｐ＜０．０５），以上结果表明ＥＴ－１作为一种反应介质在肺心病病情发展、电解质紊乱及病情加重中起一定的作用。We determined plasma ET 1level in forty five patients with acute attack of chronic cor pulmonale by RIA technique and analyzed the relationship between ET 1 and other indexes including age,blood K +,Na +,Cl +,Cr,BUN,CO 2CP,urine protein and seriousness of disease.Rusults showed that plasma ET 1 level is much higher in chronic cor pulmonale than in control,and that the more serious the diseaee is,the higher the plasma ET 1 level is.Plasma ET 1 relates to blood K + and Na +(P<0 05)but it does not relate to age,blood Cl -,Cr,BUN,CO 2CP,and urine protein.This indicated that ET 1 as a reactive mediator plays some roles duing the progression of chronic cor pulmonale and occurrence of electrolyte disorder.

关 键 词：肺心病 内皮素 血浆 

分 类 号：R541.504[医药卫生—心血管疾病]