40mg阿托伐他汀短期内对ACS患者血清炎症因子的影响  

Effect of 40mg Short-term Atorvastatin on Inflammatory Factors in Patients with Acute Coronary Syndrome

作　　者：舒君[1] 赵水平[1] 陈琛[1] 蒋云[1] 许丹焰[1] 

机构地区：[1]中南大学湘雅二医院心内科,湖南长沙410011

出　　处：《医学临床研究》2008年第5期853-855,共3页Journal of Clinical Research

摘　　要：【目的】探讨短期内使用阿托伐他汀强化降脂对急性冠脉综合征(ACS)患者血清高敏C反应蛋白(hs-CRP)及白细胞介-素6(IL-6)的影响,以了解其对ACS炎症抑制和斑块稳定作用。【方法】70例ACS患者抽血检查后随机分为常规组35例,阿托伐他汀组35例,常规组常规治疗,不用降脂药物,阿托伐他汀组予阿托伐他汀40 mg/d,口服。所有患者药物治疗前和治疗后d3及PCI术后48 h检测血脂及hs-CRPI、L-6等指标。【结果】阿托伐他汀组hs-CRPI、L-6两项指标明显降低(P<0.05),而常规组无明显变化。PCI术后48 h,两指标浓度均有明显升高,但阿托伐他汀组升高程度明显低于常规组(P<0.05)。【结论】阿托伐他汀能迅速降低ACS患者的血清炎症因子,具有抑制炎症和斑块稳定作用。[Objective]To observe the effect of short-term atorvastatin on the inflammatory factors such as high sensitivity C-reactive protein （hs CRP） and interleukin-6 （IL-6） in patients with acute coronary syndrome, and to demonstrate that atorvastatin could aggressively inhibit inflammation and stabilize the athero sclerosis plaque. [Methods] A randomized, doubleblinded and parallel control design was made for this study. 70 cases of selected acute coronary syndrome patients were randomly divided into conventional group （ n =35） and atorvastatin group （ n = 35）. Patients in the conventional group received conventional treatment without lipid-lowing drugs, whereas patients in atorvastatin group received atorvastatin 40 mg daily besides conventional treatment. Blood lipoprotein, hs-CRP and IL-6 were measured in all patients before treatment, three days after drug therapy and 48 hours after PCI. [Results] Hs CRP and IL-6 decreased significantly （ P 〈0. 05） in atorvastatin group, while there was no significant change in the conventional group, hs-CRP and IL-6 significantly increased 48 hours after PCI in both group, however the elevated levels of hs-CRP and IL-6 were significantly lower in atrovastatin group than those in the conventional group. [Conclusion] Atorvastatin could rapidly reduce serum inflammatory factors in patients with acute coronary syndrome, thus might inhibit inflammation and stabilize atherosclerosis plaque.

关 键 词：冠状动脉疾病/药物疗法 降血脂药/投药和剂量 炎症趋化因子类/血液 

分 类 号：R543.3[医药卫生—心血管疾病]