质谱技术及其在后基因组时代中的应用  被引量:4

Development Research on Mass Spectrometry and Prospect in Post-genomics

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作  者:田双起[1] 秦广雍[1] 李宗伟[1] 王雁萍[1] 陈林海[1] 谈重芳[1] 李宗义[1] 黄新[1] 常胜合[1] 

机构地区:[1]郑州大学离子束生物工程省重点实验室,郑州450052

出  处:《生物技术通报》2008年第3期50-53,共4页Biotechnology Bulletin

基  金:国家重点基础研究发展计划973项目(2004CB719604)

摘  要:蛋白质组学的建立开辟了功能基因组学研究的新领域,为研究蛋白质水平的生命活动展现了更为崭新的思路和广阔的前景。质谱技术能准确测量肽和蛋白质的相对分子质量、氨基酸序列及翻译后修饰,成为连接蛋白质与基因的重要技术。质谱技术联合蛋白质组学多角度、深层次探索生命系统分子本质成为现阶段生命科学研究领域。简要综述了肽和蛋白质等生物大分子质谱分析的原理、方式和应用,并对其发展前景做出展望。As establishing of proteomics,the study of functional genomics is coming a new areas,which has demonstrated more innovative ideas and broad prospects at protein levels for the study of life activities. Mass spectrometry can accurately measuring the weight of the peptide and protein molecular,amino acid sequence and post-translational modification. Therefore mass spectrometry become an important technology linking protein and gene indisputably.The potential for current methods to uncover new types of information and to encode biological systems at a molecular level make mass spectrometry and proteomics among the most exciting and important research themes at the present time. In this article,the basis principles and limits of currents mass spectrometric methods that are the basis for proteomics analysis were summarized,together with a description of the development of newer proteomics strategies for protein identification.

关 键 词:质谱技术 蛋白质组 基因组 

分 类 号:Q78[生物学—分子生物学]

 

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