大环内酯类药物治疗铜绿假单胞菌慢性感染机制的研究进展  

Research progress in the mechanism of macrolides in the treatment of chronic Pseudomonas aeruginosa infections

作　　者：万珍艳[1] 余加林[1] 

机构地区：[1]重庆医科大学附属儿童医院,重庆400014

出　　处：《中国抗生素杂志》2008年第5期265-268,320,共5页Chinese Journal of Antibiotics

摘　　要：近年来大量研究表明长期应用大环内酯类药物或大环内酯类药物与其它抗生素联用均能有效控制铜绿假单胞菌所致的慢性感染。大环内酯类在治疗铜绿假单胞菌慢性感染方面主要具有:①抑制铜绿假单胞菌藻酸盐和表多糖的产生;②影响铜绿假单胞菌III型分泌系统,减少毒力因子的产生;③破坏铜绿假单胞菌表面结构,抑制细菌对宿主的黏附;④抑制细菌QS系统,减少自身信号诱导分子的合成;⑤增加炎症细胞聚集,减少炎性细胞凋亡,对抗机体的炎症反应;⑥增加呼吸道痰液的清除,降低痰液粘稠度;⑦对铜绿假单胞菌具有暴露时间依从性杀菌活性等方面的功能,能最终达到对铜绿假单胞菌慢性感染的有效控制。Recent years, plenty of experiments have demonstrated that long-term use of macrolide or combined with other antibiotics therapy in chronic Pseudomonas aeruginosa infections have had positive results. The mechanisms of macrolides to chronic Pseudomonas aeruginosa infections is likely attributable to seven predominant effects： ① inhibition of production of Pseudomonas aeruginosa alginate and exopolysaccharide; ②modulation of bacterial type Ⅲ secretion,reduction of bacterial virulence factors; ③impairing bacterial cell surface structures and surpressing adherence to host cells; ④inhibition of quorum sensing in Pseudomonas aeruginosa, reduction of quorum-sensing signal molecule synthesis; ⑤increasing inflammatory cell collection, reduction of inflammatory cell apoptosis ; ⑥suppressing sputum production, decreasing viscosity and improving sputum clearance, and ⑦exposuring time-dependent killing Pseudornonas aeruginosa acticity.

关 键 词：大环内酯类 铜绿假单胞菌 感染 

分 类 号：R978.15[医药卫生—药品]