皮肤良恶性病变DNA原位定量AgNORs的图象分析  

DNA content measurement and AgNORs image analyses in benign and malignant cutaneous lesions

作　　者：王晓彦[1,2,3] 夏养志[1,2,3] 刘淑华[1,2,3] 李宗学[1,2,3] 王迎林[1,2,3] 王泽民[1,2,3] 

机构地区：[1]内蒙古医学院附院皮肤科 [2]内蒙古医学院病理教研室 [3]内蒙古医学院数学教研室

出　　处：《临床皮肤科杂志》1997年第6期353-355,共3页Journal of Clinical Dermatology

基　　金：内蒙古自治区教育厅资助

摘　　要：应用彩色病理图象分析仪对６１例皮肤良恶性病变进行ＤＮＡ原位定量及ＡｇＮＯＲｓ的图象分析，结果表明，皮肤癌的ＤＮＡ倍体多呈现Ｃ５、＞Ｃ５，ＡｇＮＯＲｓ的图象分析示３种变量即ＧＮ（颗粒数目）、ＧＡ（颗粒面积）、ＧＶ（颗粒的变异系数）意义较大，在良恶性皮肤病中差异非常显著（Ｐ＜０．０１）。研究表明，ＤＮＡ原位定量与ＡｇＮＯＲｓ的图象分析对判断皮肤良恶性病变。DNA content and several parameters of AgNORs were determined by HICI image analysis system in 61 cases of benign and malignant cutaneous lesions. The results indicated that DNA content of most cutaneous carcinomas was C5 and/or >C5. 3 parameters of AgNORs, which was GN(granule number)、GA(granule area)、GV(granule viriability), were significantly different in benign and malignant cutaneous lesions (P<0.01). It was suggested that DNA content and AgNORs parameters measured by image analysls were of use in the diagnosis of benign and malignant skin diseases and discriminating several kinds of skin carcinomas and preevaluating lesions which could transform into malignancy.

关 键 词：DNA AGNORS 图象分析 皮肤病变 良性 恶性 

分 类 号：R751.04[医药卫生—皮肤病学与性病学] R739.504[医药卫生—临床医学]