Effect of Xiaoyu Zhixue Tablet(消瘀止血片) on the Expression of Platelet Membrane Glycoprotein Ⅰb/Ⅸ/Ⅴ Complex in Patients with Chronic Renal Failure  

作　　者：秦铀 沈霖 卢芙蓉 石威 刘建国 

机构地区：[1]Department of Integrated Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology

出　　处：《Chinese Journal of Integrative Medicine》2008年第2期83-87,共5页中国结合医学杂志（英文版）

基　　金：the National Natural Science Foundation of China(No.30572441)

摘　　要：Objective： To investigate the effect of Xiaoyu Zhixue Tablet （消瘀止血片, XYZXT） on the expression of platelet membrane glycoprotein （GP） Ⅰ b/Ⅸ/Ⅴ complex and GP Ⅰ b α in patients with chronic renal failure （CRF） in early metaphase. Methods： Fifty-one patients with CRF in early metaphase （treated group） were treated with XYZXT, 3 months as the course of treatment for 2 courses. The previous therapies remained unchanged. Flow cytometry was used to assess the expression of platelet GP Ⅰb/Ⅸ/Ⅴ complex and GP Ⅰb α in patients with CRF, and turbidity method was used to determine the platelet maximum aggregation rate （MAR）, meanwhile the renal function was measured. The final data were compared with those before the treatment, and with those in the normal control group （31 healthy subjects）. Results： Compared with the normal control group, expressions of GP Ⅰ b/Ⅸ/Ⅴ complex and GPⅠb α, and platelet MAR in CRF patients were significantly lower （P=0.007,P=0.001,P=0.009） before the treatment; after the treatment with XYZXT, the above indexes in CRF patients were remarkably increased （P=0.033,P=0.026, P=0.045）, but still lower than those in the normal control group, however, it was not statistically significant. Conclusion： （1） The expression of GP Ⅰ b/Ⅸ/Ⅴ complex in CRF patients of early metaphase was decreased, which lead to platelet aggregation dysfunction. This might be one of the reasons for the hemorrhagic trend in CRF. （2） XYZXT was able to upgrade expressions of GP Ⅰb/Ⅸ/Ⅴ complex and GPⅠb α in CRF patients, improve platelet function and clown-regulate platelet activation in patients with CRF.

关 键 词：chronic renal failure platelet membrane glycoproteins platelet maximum aggregation rate Xiaoyu Zhixue Tablet 

分 类 号：R277.5[医药卫生—中医学]