广东地区溃疡性结肠炎20年比较分析  

A Twenty Years Comparative Analysis of Ulcerative Colitis in Guangdong District

作　　者：宋卫生[1] 陈新杰[1] 于长辉[1] 黄纯炽[1] 毛华[1] 

机构地区：[1]南方医科大学珠江医院消化内科,广州510282

出　　处：《中国消化内镜》2008年第3期16-18,共3页Digestive Disease and Endoscopy

摘　　要：目的了解广东地区溃疡性结肠炎的发病情况和病情特点。方法回顾性总结研究我院最近20年溃疡性结肠炎住院病例,并对前、后10年作比较分析。结果20年住院患者共224例,后10年(169例)显著多于前10年(55例,P<0.01);后10年平均年龄(45.4岁)显著高于前10年(37.5岁,P<0.05);后10年全结肠炎和广泛结肠炎(37.9%)显著多于前10年(20.0%,P<0.01);后10年重度患者(29.6%)显著多于前10年(16.4%,P<0.01)。后10年肠外表现(11.2%)显著多于前10年(5.5%,P<0.05)。内科治疗总有效率后10年(93.5%)与前10年(94.6%,P>0.05)差异无显著意义。结论广东地区溃疡性结肠炎的发病情况和病情特点与国内报道基本相似。前、后10年比较显示,广东地区后10年住院患者是前10年的3.1倍,发病年龄显著增加,病情程度明显加重,但治疗效果无显著差异。Objective： To understand the incidence and the clinical characteristics of ulcerative colitis （UC） in Guangdong District. Methods： A retrospective study was performed to evaluate the clinical data of hospitalized patients with UC in Zhujiang Hospital from 1987 to 2006. And this time period was divided into two decades in front and behind to compare and analyze. Results： During the study period, a total of 224 cases were identified. Among them, the incidence of UC in the second decade （1997-2006, 169 cases） was found much higher than those in the fast decade （1987-1996, 55 cases, P〈0.001）. The mean age at diagnosis was also higher in the second decade （45.4 years） which compared to the first decade （37.5 years, P〈0.05）. Of the patients, 18.2% and 36.1% in the first and second decades were diagnosed with pancolitis and extensive colitis （P〈0.001 ）; 16.4% in the fast decade and 29.6% in the second decade had severe UC （P〈0.01）. Furthermore, 5.5% in the first decade and 11.2% in the last decade had extraintestinal manifestations （P〈0.05）. In contrast, the efficancies of medical treatments were similar in the fast （94.6%） and second （93.5%） decades （P〉0.05）. Conclusion： This study revealed that the incidence and clinical characteristics of ulcerative colitis in Guangdong District were similar to other medical reports in China. Compared to the fast decade, the number of the UC patients in the last decade had increased 3.1 times, the age of pathogenesis became older, and the condition of disease became heavier. However, the outcomes of treatment had no significant change.

关 键 词：溃疡性结肠炎 临床分析 比较分析 广东地区 

分 类 号：R259.746.2[医药卫生—中西医结合] R651.15[医药卫生—中医内科学]