HLA-B27抗原检测的临床意义  

THE CLINICAL SIGNIFICANCE OF ANTIGEN DETECTION OF HLA-B27

作　　者：张向阳[1] 郑海萍[1] 门金娥[1] 

机构地区：[1]河北工程大学临床医学院中心试验室,邯郸056029

出　　处：《现代预防医学》2008年第11期2174-2175,共2页Modern Preventive Medicine

摘　　要：[目的]探讨HLA-B27抗原检测的临床意义。[方法]使用流式细胞仪对350名随机人群、356名强直性脊柱炎(AS)疑似患者和70名AS患者进行HLA-B27抗原检测。[结果]随机人群、AS疑似患者和AS患者的HLA-B27阳性率分别为2.29%、45.79%和91.43%,AS疑似患者的HLA-B27阳性率显著高于随机人群(P﹤0.01),AS患者的HLA-B27阳性率显著高于AS疑似患者(P﹤0.01)。AS疑似患者中,男性患者的阳性率显著高于女性患者(P﹤0.01),青年患者的阳性率显著高于老年患者(P﹤0.01)。[结论]在AS疑似患者中,尤其是青年男性,开展HLA-B27抗原检测有着重要的临床意义。[Objective] To discuss the clinical significance of antigen detection of HLA-B27. [Methods] Detected the HLA-B27 antigen of 350 schizophrenic patients, 356 skeptical AS patients and 70 AS patients with flow cytometer. [ Results] The positive rate of HLA-B27 of schizophrenic patients, skeptical AS patients and AS patients was 2.29%, 45.79% and 91.43% respectively. The positive rate of HLA-B27 of skeptical AS patients was significantly higher than that of schizophrenic patients （P 〈 0.01 ）. The positive rate of HLA-B27 of AS patients was significantly higher than that of skeptical AS patients （P 〈 0.01 ）. In skeptical AS patients, The positive rate of HLA-B27 of young people was significantly higher than that of old AS patients （P 〈 0.01）. The positive rate of HLA-B27 of male was significantly higher than that of female （P 〈 0.01 ）. [Conclusion] In skeptical AS patients, especially young men, there was a remarkable clinical significance in detecting HLA-B27 antigen.

关 键 词：HLA-B27 强直性脊柱炎 流式细胞仪 

分 类 号：R392.11[医药卫生—免疫学]