经鼻持续气道正压通气治疗睡眠呼吸暂停低通气综合征合并冠心病临床研究  

Nasal continuous positive airway pressure in the treatment of obstructive sleep apnea/hypopnea syndrome with coronary heart disease

作　　者：赵军[1] 郝芙蓉[3] 汪贺媛[2] 魏小刚[1] 

机构地区：[1]石家庄市第一医院心内科,河北省050001 [2]石家庄市第一医院耳鼻喉科,河北省050001 [3]河北医科大学附属第二医院耳鼻喉科

出　　处：《中国综合临床》2008年第6期519-521,共3页Clinical Medicine of China

基　　金：河北省科技厅攻关项目（0627611093）

摘　　要：目的探讨经鼻持续气道正压通气（nCPAP）治疗阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并冠心病的疗效和机制。方法选择OSAHS合并冠心病患者126例，随机分为2组，观察组在原药物治疗基础上加用nCPAP治疗，对照组继续原药物治疗3个月，观察动态心电图变化，单纯药物及药物联合nCPAP治疗效果。结果2组比较，夜间心肌缺血发生率明显下降（55．6％和6．35％，P〈0．05）。结论nCPAP治疗可以消除呼吸暂停，纠正低氧血症，降低夜间平均心率和平均收缩压，降低心肌缺血发生率，从而降低心血管终点事件发生率。Objective To obsmwe the effect and mechanism of nasal continuous positive airway pressure （ nCPAP ） in the treatment of obstructive sleep apnea/hypopnea syndrome （ OSAHS ） with coronary heart disease. Methods 126 OSAHS patients with coronary heart disease were randomly divided into two groups. The treatment group was treated by nCPAP on the basis of former medicine but the control group was treated by former methods. Three months later, polysomnography（PSG） and the holter ECG examination were conducted. Results After three months,the nocturnal myocardial ischemia episodes decreased significantly in both groups（55.6% and 6.35% ,P 〈 0.01 ）. ConcLusion nCPAP may abolish sleep apnea and hypopnea, correct hypoxemia, reduce the nocturnal mean heart rate and systolic blood pressure, and improve myocardial ischemia episodes, so to reduce the incidence of cardiac end-point events.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 冠心病 持续气道正压通气 

分 类 号：R766[医药卫生—耳鼻咽喉科]