COX-2、Ki-67与乳腺癌新辅助化疗疗效的关系  

Correlation between expression of COX-2,Ki-67 and neoadjuvant chemotherapy in breast cancer

作　　者：蔡凤林[1] 周士福[1] 马兆生[1] 时伟锋[1] 吴玉玉[2] 高玮红[2] 

机构地区：[1]苏州大学附属第四医院肿瘤外科,无锡214062 [2]苏州大学附属第四医院病理科,无锡214062

出　　处：《中国医师进修杂志（外科版）》2008年第6期9-11,共3页Chinese Journal of Postgraduates of Medicine

基　　金：江苏省无锡市科技发展项目（CS040007）

摘　　要：目的 研究COX-2、Ki-67在乳腺癌新辅助化疗前后的表达变化及其与新辅助化疗疗效的关系。方法 应用免疫组织化学法检测48例乳腺癌新辅助化疗前后标本中COX-2、Ki-67的表达。结果新辅助化疗总有效率为70．8％，总临床获益率为95．8％。化疗前后COX-2阳性率、Ki-67指数变化显著，分别由化疗前的62．5％和（46．81±23．17）％，降到化疗后的41．7％和（33．23±18．11）％，P〈0．05。化疗前后COX-2阳性的乳腺癌组织中Ki-67指数均显著高于COX-2阴性者，P〈0．01。新辅助化疗后COX-2表达阳性者，化疗效果差（P〈0．05）；而Ki-67高表达者总有效率高于低表达者（P〈0．05）。结论 COX-2、Ki-67可作为指导乳腺癌新辅助化疗并预测化疗敏感性的分子生物学指标。Objective To study the correlation between expression of COX-2, Ki-67 and neoadjuvant chemotherapy in breast cancer. Method COX-2 and Ki-67 were examined by immunohistochemical staining in 48 breast cancer samples. Results The overall response rate and clinical benefit rate to neoadjuvant chemotherapy were 70.8% and 95.8% ,respectively. The expression of COX-2 and Ki-67 after the chemotherapy [41.7% and （33.23 ± 18.11）% ] was significantly lower than those in prechemotherapy [62.5% and （46.81 ± 23.17）%], P〈 0.05. Ki-67 index was higher in COX-2 positive tumors than that in the COX-2 negative ones before and after neoadjuvant chemotherapy, P 〈 0.01. The effect of neoadjuvant chemotherapy had a significantly negative correlation with COX-2 expression. Patients with high expression of Ki-67 were more likely to respond to treatment. Conclusion The expression of COX-2 and KI-67 as molecular markers could be a guide for chemotherapy and prediction for neoadjuvant＇s response to chemotherapy in breast cancer.

关 键 词：乳腺肿瘤 KI-67抗原 新辅助化疗 COX-2 

分 类 号：R651.15[医药卫生—外科学] R730.264[医药卫生—临床医学]