五苓散的毒性评价  

Evaluation of Toxicity of WLS

作　　者：张银卿[1] 王宁生[1] 刘启德[1] 叶少梅[1] 欧卫平[1] 

机构地区：[1]广州中医药大学临床药理所,510405

出　　处：《中国现代药物应用》2008年第12期16-18,共3页Chinese Journal of Modern Drug Application

摘　　要：目的对五苓散(WLS)的长毒作用进行评价。方法观察给药后大鼠的一般症状、血液学、血液生化学、系统尸检和恢复期的有关指标,对WLS进行安全毒理学评价。结果对血液学及血液生化指标有一定的影响,主要表现在白细胞数分类及血红蛋白的改变(有统计学意义),但停药后基本恢复。三个剂量组大鼠的心、脾、肺、肾上腺、前列腺、卵巢、子宫或睾丸(连附睾)、脑等脏器系数均无明显改变。结论临床应用需注意肝、肾脏和睾丸等脏器的毒性表现。Objective The aim of this work was to evaluate the long-term toxic effects of WLS. Methods Targets were observed after oral administration of WLS. Results Some targets were influenced after oral administration of WLS （P 〈 0. 05 ）, Conclusion The toxic effects of some organ such as liver, kidney and testicle should be paid attention when it used in clinical therapy.

关 键 词：五苓散 长毒药效实验 毒性 脏器 

分 类 号：R289[医药卫生—方剂学]