核-壳结构壳聚糖/聚乙烯醇-聚碳酸亚丙酯超细纤维的制备  

PREPARATION OF CORE-SHELL STRUCTURED CS/PVA-PPC FIBERS BY COAXIAL ELECTROSPINNING

作　　者：靳钰[1] 聂俊[1] 周应山[1] 杨冬芝[1] 

机构地区：[1]北京市新型高分子材料制备与加工重点实验室北京化工大学,北京100029

出　　处：《高分子学报》2008年第5期410-415,共6页Acta Polymerica Sinica

摘　　要：利用同轴电纺丝技术制备出具有核-壳结构的壳聚糖/聚乙烯醇-聚碳酸亚丙酯电纺丝纤维,考察了溶剂复配对成纤的影响,采用扫描电镜和透射电镜对纤维的形貌、结构、直径分布等进行了探索,并在优化的工艺条件下,将羟基磷灰石负载在内层结构中.研究表明,采用氯仿/N,N-二甲基甲酰胺(1/1)复配溶剂可有效避免聚合物溶液在喷丝口处的凝结现象.同单纺纤维相比,核壳结构的纤维直径分布较宽,纤维壳层和核层界限清晰;红外谱图分析证明羟基磷灰石可负载在纤维的核结构中.The preparation of core-shell fibers was of particular interest for those core materials that would not form fibers via electrospinning by themselves, and co-electrospinning could also facilitate manufacturing of polymer nanotubes. Furtheremore, coaxial electrospinning would provide an ahemative and simple means to encapsulate drugs to deliver a biomolecular drug in a sustained fashion. In this study, core-shell structured chitosan （CS）/poly（vinyl alcohol） （PVA）-poly（ propylene carbonate） （PPC） fibers were prepared by coaxial electrospinning. The coaxial electrospinning setup in this study was a compound spinneret, consisting of two concentrically arranged capillaries that were flatted stainless steel needles. A certain amount of the two polymer solutions were contained separately in two plastic syringes connected to the coaxial spinneret, and the flow rate in each capillary was adjusted in a double- way medical syringe pump. The liquid flowing on the outside was PPC solution, and the inner liquid was CS/PVA solution. First, the effects of mixed solvents on electro-spinnability of PPC solutions were investigated to choose an appropriate solution system using a conventional electrospinning setup. The properties of PPC solutions in chloroform/ dimethylformamide （DMF） mixed solvents with different volume ratios were tested, and the solution conductivity had a tendency to increase ranged from 0.02 to 13.43 μs· cm^-1 when DMF proportion had increased. The morphology and diameter of fibers were determined with scanning electron microscopy （SEM）. The results indicated that the use of chloroform/DMF （ 1/1 ） mixed solvents could avoid agglomeration of polymer at the capillary tip during coaxial electrospinning process, and contributed to good morphology and most narrow fiber distribution of the fibers （300 - 600 nm）. Secondly, the morphology and structure of the core-shell fibers were characterized by SEM and transmission electron microscopy （TEM）.In addition,hydroxyapatite （HAp

关 键 词：静电纺丝 核-壳结构 壳聚糖 聚碳酸亚丙酯 

分 类 号：TQ342.8[化学工程—化纤工业]