一种可注射可降解磷酸钙骨水泥的结构与性能  

Structure and properties of an injectable and degradable calcium phosphate cement

作　　者：叶建东[1] 王秀鹏[1] 白波[2] 徐谦[2] 

机构地区：[1]华南理工大学特种功能材料教育部重点实验室 [2]广州医学院第一附属医院骨科,广东广州510120

出　　处：《功能材料》2008年第2期271-274,278,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(50172015);广东省自然科学基金资助项目(04205786,011561)

摘　　要：通过采用部分结晶磷酸钙和磷酸氢钙制备了新型可注射可降解磷酸钙骨水泥。研究表明:该材料具备优良的可注射性能,并通过添加变性淀粉,显著改善了材料的抗溃散性能,骨水泥的水化产物是直径和长度在分别约为100和1000nm左右的棒状类骨羟基磷灰石。所研制的骨水泥在体温(37℃)条件下凝结较快,而在室温(25℃)和冷藏温度(5℃)可在较长时间保持不固化,这就为骨水泥的临床应用提供了很有利的条件。体外溶血试验、体外细胞毒试验、热原性试验、小鼠的急性毒性试验、微核试验、豚鼠的致敏性试验、小鼠的肌内埋植试验及兔的骨内埋植试验等一系列毒性及生物相容性试验表明该材料无毒副作用,具有良好的生物相容性。复合rhBMP-2的可注射磷酸钙骨水泥植入猕猴椎体后的近远期影像学和组织学观察表明,骨水泥可降解且降解和新骨长入基本同步。A novel injectable and degradable calcium phosphate cement was prepared by partially crystallized calciumphosphate（PCCP） and dicalcium phosphate（DCP） in this study.This cement showed excellent injectability.With the addition of modified starch,the anti-washout property of the cement was greatly improved.The hydration product of the cement was rod-like hydroxyapatite with a diameter of about 100 nm and a length of 1000nm.This cement set fast at body temperature（37℃）,but set slowly at room temperature（25℃） and very slowly under refrigerate temperature（5℃）.This performance provides great convenience for the clinical application of the cement.The in vitro hemolysis test, in vitro cytotoxicity test,acute systemic toxicity test,micronucleus test,sensibilization test,intramuscularly implanting test,and bone implanting test showed that the cement was biocompatible and bioactive.Radiographic and histological studies showed that,after implanted in vertebroplasty of macaque,the rhBMP-2/calcium phosphate cement degrade in accord with the new bone generation.

关 键 词：磷酸钙骨水泥 可注射 可降解 抗溃散 

分 类 号：Q66[生物学—生物物理学]