类雌激素农药对雌性哺乳动物的生殖毒理研究  

Study on reproductive toxicity in female mammals of xenoestrogenic pesticides

作　　者：杨彩霞[1] 潘志彦[1] 赵美蓉[1] 王鲁梅[1] 刘维屏[1] 

机构地区：[1]浙江工业大学环境科学研究中心,浙江杭州310032

出　　处：《浙江工业大学学报》2008年第2期122-128,共7页Journal of Zhejiang University of Technology

基　　金：教育部创新团队项目(IRT0652);浙江省自然科学基金重大项目(Z506070)

摘　　要：环境雌激素类化合物对生态系统和人口健康造成的危害日益受到人们的关注.农药作为环境雌激素的一大类,影响雌性哺乳动物的内分泌系统,导致生殖和发育方面的畸形.笔者介绍了环境雌激素的概念及其对雌性哺乳动物的毒性作用,并着重从雌性哺乳动物激素水平、生殖器官、胚胎三个方面阐述了环境雌激素类农药对雌性哺乳动物生殖生理的影响及其分子机理.环境雌激素类农药中有相当一部分是手性农药,因此就手性农药对雌性哺乳动物生殖毒性研究的重要性和研究现状进行了评述,并对该领域今后的研究进行了展望.Some pesticides may interfere with the female mammal hormonal function, which may lead to negative effects on the reproductive system through disruption of the hormonal balance necessary for proper functioning. The purpose of this review is to give an overview of the various ways in which xenoestrogenic pesticides may disrupt the female reproductive system, including hormone regulation, reproductive organs and embryo development. What＇s more, the molecular mechanisms are described for effects of pesticide exposure in vitro and on experimental animals in vivo. Most of xenoestrogenic pesticides are chiral pesticides, the structure of pesticides effects mammals reproduction also was introduction.

关 键 词：环境雌激素 手性农药 雌性哺乳动物 生殖毒理 

分 类 号：R994.6[医药卫生—毒理学]