栝楼瞿麦丸对糖尿病肾病大鼠肾脏保护作用的实验研究  

Protective effect of gualouqumai pills on kidney in rats with diabetic nephropathy

作　　者：马晓峰[1] 张建梅[1] 周霞继[1] 吕娟[1] 王伟[1] 

机构地区：[1]天津中医药大学金匮教研室,天津300193

出　　处：《天津中医药》2008年第3期220-222,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市高等学校科技发展基金计划项目(津20050323)

摘　　要：[目的]以实验性糖尿病肾病(DN)大鼠为研究对象,观察并探讨《金匮要略》栝楼瞿麦丸对肾脏病变的治疗作用。[方法]将80只雄性SD大鼠随机分为5组,即空白对照组,模型组,栝楼瞿麦丸低剂量组,中剂量组,高剂量组。采用左肾切除、尾静脉注射链脲佐菌素(STZ)的方法造模后,依不同剂量分别给药共6周。于第6周末检测尿量,尿蛋白,尿素氮,血肌酐,计算肌酐清除率。[结果]栝楼瞿麦丸可减少尿蛋白排泄,降低血肌酐、尿素氮水平。[结论]栝楼瞿麦丸对糖尿病肾病大鼠肾功能有一定的保护作用。[Objective] To observe and explore the effects of Gualouqumai pills （Bolus of Fructus Trichosanthis Herba Dianthi） the pathologic cbanges of kidney in rats with diabetic nephropathy. [Methods] Eighty male SD rats were randomly divided into control group （C）, model group （M）,low-dose Gualouqumai pills group（L-D）, middle-dose Gualouqumai pills group（M-D） and high-dose Gualouqumai pills group（H-D）. The left kidneys in model rats were nephrectomized and streptozocin （STZ） was injected. Depending on the dose, all the rats were administrated for 6 weeks. At the end of the experiment the urine, urinary protein（Upro）, blood urea nitrogen（BUN） and serum creatinine（Scr） were measured and the endogenous creatinine clearance rate （Ccr） was calculated. [Results] Gualouqumai pills had a function of decreasing the excretion of brine protein and reducing the level of blood creatinine and urea nitrogen. [Conclusions] Gualouqumai pills can play a certain role in protecting and treating the rats with diabetic nephropathy.

关 键 词：栝楼瞿麦丸 尿蛋白 尿素氮 糖尿病肾病大鼠 

分 类 号：R285.5[医药卫生—中药学]