钴合金裸支架与雷帕霉素药物涂层支架在冠心病患者应用中的对比研究  

Comparison between Sirolimus-eluting Stents and Cobalt Alloy Bare Stents in Coronary Artery Disease

作　　者：王勇[1] 曲华[2] 齐国先[1] 

机构地区：[1]中国医科大学附属第一医院心内科,沈阳110001 [2]沈阳医学院沈洲医院神经内科,沈阳110002

出　　处：《中国医科大学学报》2008年第3期374-375,379,共3页Journal of China Medical University

基　　金：国家教育部春晖计划基金资助项目(Z2005-1-21008)

摘　　要：目的比较冠状动脉内钴合金裸支架与雷帕霉素药物支架特点、临床应用的安全性和有效性,探讨钴合金裸支架治疗单支冠状动脉病变冠心病患者的安全性和临床疗效。方法分析经选择性冠状动脉造影(CAG)证实为单支病变血管直径狭窄>70%的冠心病患者204例,81例冠状动脉内置入钴合金裸支架;123例冠状动脉内置入雷帕霉素药物涂层支架,观察术后疗效、12个月内主要不良心脏事件(MACE)发生率及再狭窄率。结果两组手术成功率均为100%。两组患者置入支架的成功率、住院期间急性及亚急性血栓形成率及12个月随访MACE发生率、再狭窄率等差异无统计学意义。结论钴合金裸支架可以安全有效的应用于单支冠状动脉病变的治疗。Objective To compared with the characteristics,clinical safety and validity of Sirolimus-eluting steuts and Cobalt alloy bare steuts. Methods 204 patieuts with coronary artery stenosis over 70 % in area continued by coronary angiography were enrolled in this study. Cobalt alloy bare steuts were implanted in 81 patieuts,and Sirolimus-eluting steut were implanted in 123 patieuts. The therapeutic effect,major adverse cardiac eveuts （MACE） and resteuosis were iuvestigated. Results Rates of successful operation were 100 % in both groups. There was no significant difference between two groups of patients in steut implantation success rate duriug hospitalization and in MACE rate during 12-mouth follow-up. The aspect of depressing the resteuosis rate of Sirolimus-eluting stent surpassed that of Cobalt alloy bare stents. Conclusion Sirolimus-eluting stents and Cobalt alloy bare stents are safe and effective in coronary artery disease.

关 键 词：冠状动脉疾病 雷怕霉素 钴合金 支架 再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]