碱性阴离子交换树脂催化酯交换反应制备 1-羟基-2-甲基-4-乙酰氧基-2-丁烯的研究  

Ester Exchange Reaction Catalyzed by Basic Anion-Exchanged Resins to Prepare 1-Hydroxy-2-methyl-4-acetyloxy-2-butene

作　　者：叶伟东[1] 沈润溥[2] 虞国棋[1] 张伯引[1] 王奎[1] 

机构地区：[1]浙江医药股份有限公司新昌制药厂,浙江新昌312500 [2]绍兴文理学院化学化工学院,浙江绍兴312000

出　　处：《高校化学工程学报》2008年第2期316-319,共4页Journal of Chemical Engineering of Chinese Universities

基　　金：绍兴市重点科研项目(2003109)

摘　　要：用碱性阴离子交换树脂催化1-甲酰氧基-2-甲基-4-乙酰氧基-2-丁烯进行酯交换反应制备1-羟基-2-甲基-4-乙酰氧基-2-丁烯,反应的选择性由85%提高到99.5%,并因采用反应精馏的方式将反应时间由12h缩短到5h,收率由77%提高到93%,后处理方便,具有重要的工业意义;这一改进对类似的反应也有重要意义。A new process of ester exchange reaction for producing 1-hydroxy-2-methyl-4-acetyloxy-2-butene from 1-formyloxy-2-methyl-4-acetyloxy-2-butene was proposed.The basic anion-exchanged resin was used as catalyst instead of the conventionally used NaHCO3,and the reaction-distillation method was adopted to simplify the ester exchange process.The results show that the new process proposed can enhance the selectivity of the ester exchange reaction from 85% to 99.5%,shorten the reaction time from 12 h to 5 h,and increase the yield of the product from 77% to 93%.Moreover,the post-treatment of the ester exchange process proposed is more convenient.All these demonstrate that the proposed new process has great industrial value and referential significance for the synthesis of similar compounds via ester exchange reaction.

关 键 词：VA乙酸酯 1-羟基-2-甲基-4-乙酰氧基-2-丁烯 酯交换反应 碱性阴离子交换树脂 反应精馏 

分 类 号：TQ323.41[化学工程—合成树脂塑料工业] P734.41[天文地球—海洋化学]