充血性心力衰竭患者血浆内阿片肽和精氨酸加压素的浓度及其相互作用关系  

RELATIONSHIP BETWEEN PLASMA LEVELS OF ENDOGENOUS OPIOID PEPTIDES AND ARGININE VASOPRESSIN IN PATIENTS WITH CONGESTIVE HEART FAILURE

作　　者：李春盛[1] 田茹敏[1] 李爱民[1] 齐平[1] 高秀兰[1] 

机构地区：[1]北京军区总医院急诊科,北京100700

出　　处：《急诊医学》1997年第6期340-342,共3页

摘　　要：目的：探讨血浆内阿片肽和精氨酸加压素（AVP）在充血性心力衰竭中的作用及其相互关系。方法：应用放射免疫法。结果：心衰组血浆β内啡肽、强啡肽和精氨酸加压素浓度比正常组明显升高（P＜0．001），其中轻中度心衰组三种激素含量显著低于重度心表组（P＜0．05）。结论：心衰时三种激素平行升高可能是由于应激所致，它们在功能方面相互拮抗，共同升高，使抗体在应激状态下能够维持内环境的相对平衡和稳定。Aim: Role and relationship between plasma levels of endogenous opioid peptides (EOP) and arginine vasopressin (AVP) in patients with congestive heart failure (CHF) were investigated. Methods: Radioimmunoassay was used. Results: Plasma levels of β-endorphin (β-EP), dynorphin (DP) and AVP were significantly higher in CHF group than that in normal control group (P<0.001). Three hormones were significantly lower in mild heart failure group than those in severe heart failure group (P<0.05). Conclusiou: High plasma levels of three hormones in heart failure may be stress-related.The increases of plasma levels of EOP and AVP are in parallel to maintaining each other. They are important in the stability of internal environment during stress.

关 键 词：心力衰竭 Β内啡肽 强啡肽 精氨酸加压素 

分 类 号：R541.61[医药卫生—心血管疾病]