呼吸机相关性肺炎病原菌流行病学研究  

Study on Pathogens in Ventilator-associated Peneumonia

作　　者：范书山[1] 周亚滨[1] 李晓丽[2] 田锁臣[2] 金红[2] 

机构地区：[1]山东大学医学院微生物学教研室,山东济南250013 [2]山东省聊城市人民医院,山东聊城252000

出　　处：《预防医学论坛》2008年第6期525-527,共3页Preventive Medicine Tribune

摘　　要：[目的]研究呼吸机相关性肺炎(VAP)病原菌临床流行病学分布及耐药性,为防治VAP提供科学依据。[方法]前瞻性调查2007年1～12月重症监护病房VAP患者,分析VAP患者临床资料、病原菌谱及耐药性。[结果]236例机械通气患者有98例发生VAP,VAP发生率为41.52%,共分离出133株病原菌,其中革兰阴性菌占72.04%,铜绿假单胞菌居于首位;革兰阳性菌占20.43%;真菌占7.53%。[结论]VAP病原菌以革兰阴性杆菌为主,并有多重耐药;革兰阳性球菌对万古霉素敏感,临床医师应根据药敏试验结果合理使用抗菌药物,及时治疗VAP。[Objective]To study the distribution and antimicrobial resistance of bacteria causing ventilator-associated pneumonia （VAP） in order to provide evidence for prevention and therapy of VAP. [Methods]Prospective study was conducted on VAP patients from January to December, 2007. [Results]Totally 236 patients were enrolled in this study, of which 98 were diagnosed as VAP. The morbidity of VAP was 41.52%, A total of 133 pathogens were identified. Among all the strains casing VAP, Gram-negative bacteria accounted for 72.04%,in which Pseudomonas aeruginosa was the major pathogen. Gram positive cocci accounted for 20.43% and 7.53% were fungi. [Conclusion]Gram-negative bacteria were the most common pathogens of VAP,which presented to multi-drug resistant pattern. Gram positive cocci to vancomycin were all 100%. Clinician should choose antimicrobial agents according to antimicrobial susceptibility test result in time.

关 键 词：呼吸机相关性肺炎 病原菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]