治疗肝炎的新武器：RNA干扰  

A New Weapon for Hepatitis： RNA Interference

作　　者：吴昊[1] 余永胜[1] 

机构地区：[1]上海交通大学第六人民医院感染科,上海200233

出　　处：《世界感染杂志》2008年第3期226-229,242,共5页World Journal of Infection

摘　　要：据统计，世界上大约有1．7亿人感染丙型肝炎病毒（HCV）和3．5亿慢性乙肝病毒（HBV）携带者。尽管用α-干扰素（IFN-α）和病毒唑联合治疗显著地提高了临床治疗效果，但是只有少于一半人对这种治疗有反应，因此需要一种新的治疗肝炎的方法。许多体内外试验发现RNA干扰能有效的抑制肝炎病毒的复制，为肝炎治疗带来新的希望。本文对RNA干扰在丙肝及乙肝方面的应用进展进行综述。About 1.7 billion people are infected with hepatitis C virus （HCV）, and 3.5 million chronic hepatitis B virus （HBV） carriers in the world according to latest statistics. Although the use of （IFN） - α and ribavirin combination therapy significantly improved clinical results, only less than half of people respond to this way, So a new method for hepatitis is needed. Many in vivo and in vitro experiments have illustrated that RNA interference can effectively inhibit replication of hepatitis virus, igniting a light for the treatment of hepatitis. In this paper, RNA interference in the progress of application in HCV and HBV are reviewed.

关 键 词：干扰RNA 小干扰RNA 肝炎 

分 类 号：R512.62[医药卫生—内科学] R512.63[医药卫生—临床医学]