乙型病毒性肝炎疫苗免疫无应答者进行再免疫的临床研究  

Clinical Research on Re-vaccinating Non-responding Persons with Hepatitis B Vaccine

作　　者：赵红娜[1] 曹明[1] 赵振峰[1] 杨鸿儒[2] 

机构地区：[1]河北省保定市传染病医院,071000 [2]中央司法警官学院校医院

出　　处：《中国全科医学》2008年第11期991-992,共2页Chinese General Practice

摘　　要：目的探讨乙型病毒性肝炎疫苗(乙肝疫苗)全程接种后免疫无应答者获得免疫保护的方法。方法从接种过全程乙肝疫苗的成人中,筛选血清乙肝病毒标志物均阴性者为研究对象,并将其随机分为对照组、观察组1和观察组2。对照组单独应用乙肝疫苗10μg肌肉注射;观察组1加量应用乙肝疫苗20μg肌肉注射;观察组2联合使用卡介菌多糖核酸和乙肝疫苗。疗程结束30d检测保护性抗体(抗-HBs)。结果对照组、观察组1和观察组2的抗-HBs阳转率分别为10%、50%和90%。观察组2抗-HBs阳转率与对照组、观察组1比较,差别有统计学意义(P<0.01)。结论对乙肝疫苗全程免疫后无应答者联合使用卡介菌多糖核酸和乙肝疫苗可诱导或激发机体抗-HBs阳转,疗效满意。Objective To investigate the immune protection method for persons who have no immune response to the whole course of inoculation by hepatitis B vaccine （HBV）.Methods The adults who were inoculated by whole course of HBV and whose marks of HBV were negative were selected as the subjects.They were at random divided as trial 1and 2,and control groups.The control subjects were only given HBV 10μg and the subjects in the group 1were given HBV 20μg intramuscularly,while the subjects in the group 2 were given BCG Polysaccharide nucleic acid plus HBV 10μg.The protective antibody（anti-HBs）was detected 30 days after the end of treatment.Results The positivity rates of anti-HBs of the control and trial 1 and 2 groups were 10%,50% and 90% respectively.The positivity rate of the trial group 2 was significantly different from form those of the control and the trial group 1（P〈0.01）.Conclusion For a person who is inoculated by whole course of HBV and whose marks of HBV is negative,BCG Polysaccharide nucleic acid combined with HBV can induce or activate the transition from negativity to positivity of anti-HBs,with a satisfactory result.

关 键 词：肝炎疫苗 乙型 免疫无应答 卡介菌多糖核酸 

分 类 号：R512.62[医药卫生—内科学]