我院地高辛血药浓度监测结果分析  

Monitoring of Blood Drug Level of Digoxin and the Analysis of Results

作　　者：田应彪[1] 陈泽慧[1] 程昌华[1] 汪世明[1] 王敏[1] 何勇[1] 

机构地区：[1]遵义医学院附属医院,遵义市563003

出　　处：《中国药房》2008年第17期1319-1320,共2页China Pharmacy

摘　　要：目的：为临床安全、有效、合理使用强心苷类药物提供参考依据。方法：采用荧光偏振免疫法测定地高辛血药浓度，对监测的结果进行统计分析。结果：在监测的126例使用地高辛的临床病例中，其血药浓度〉2．0ng·mL^-1的有32例（25．4％），0．8～2．0ng·mL^-1的有83例（65．9％），共有16例（12．7％）出现中毒症状，〈0．8ng·mL^-1的有11例（8．7％）。结论：及时监测地高辛血药浓度，对制定个体化给药方案，确保临床疗效，减少毒性反应的发生，具有十分重要的意义。OBJECTIVE： To detect the blood drug level of digoxin in order to offer reference about clinical safety and utility and rational use of cardiac glycoside drugs. METHODS： The plama concentration of digoxin was determined by fluorescence polarization immunization, and the monitoring rssults were subjected to statistical analysis. RESULTS： Of the total 126 cases who treated with digoxin, the blood drug concentration in 32（25.4% ） was above 2.0 ng ·mL^-1, and it was 0.8-2.0 ng·mL^ -1 in 83（65.9% ） and less than 0.8 ng ·mL^-1 in 11（8. 7% ）; Toxic symptoms were noted in 16 cases（ 12.7% ） . CONCLUSION： To ensure clinical efficacy and reduce incidence of toxic reactions, it is of great importance to monitior the blood drug level and formulate individual dosage regimen.

关 键 词：地高辛 血药浓度监测 合理用药 

分 类 号：R969.1[医药卫生—药理学]