氢氯噻嗪与螺内酯长期联用对高血压患者左室重量指数的影响  

Effects of Long-term Treatment with Hydrochlorothiazide Combined Spironolactone on Left Ventricular Mass Parameters in Hypertensive Patients

作　　者：李东贤[1] 邢爱君[1] 吴寿岭[1] 许继波[1] 赵海燕[1] 林黎明[1] 张冬艳[1] 

机构地区：[1]华北煤炭医学院附属开滦医院心内科,唐山市063000

出　　处：《中国药房》2008年第17期1336-1338,共3页China Pharmacy

摘　　要：目的:探讨氢氯噻嗪(HCTZ)与螺内酯长期联用对高血压患者左室重量指数的影响。方法:采用多中心双盲研究设计,选择9所开滦矿区医院,筛选出轻、中度高血压患者。入选患者经安慰剂洗脱2周,HCTZ(12.5mg,qd)导入6周后加服螺内酯(20mg,qd),共服药36个月。治疗期间每月随访1次,监测血压。洗脱期末和治疗12、24、36个月末行超声心动图测量并计算左室重量指数(LVMI),采静脉血行实验室检查。结果:治疗12个月末患者血压及LVMI出现明显下降;36个月末与12个月末比较,舒张压、LVMI进一步下降(P<0.05)。结论:HCTZ与螺内酯长期联用有效降低血压的同时,显著降低LVMI,且随治疗时间延长疗效更显著。OBJECTIVE： To explore the effects of long - term treatment with hydrochlorothiazide （HCTZ） combined spironolactone on left ventricular mass parameters in hypertensive patients. METHODS： A multicenter, double- blind study was performed. Nine Kai - luan coal mining industry hospitals took part in the trial. After 2 - week elution period （treated with placebo） and 6-week leading period （with HCTZ 12.5 mg, qd）, the eligible patients with mild-to-moderate hypertension received spironolactone （20 mg, qd） for 36 months. Follow- up of blood pressure （BP） was scheduled every month. At the end of elution period and 12, 24, 36 months, all subjects underwent a complete echocardiographic study, left ventricular mass index （LVMI） was calculated and blood sample was taken from their elbow vein for laboratory examination. RESULTS： SBP, DBP, LVMI lowered significantly after 12 months＇ treatment compared with baseline, and DBP, LVMI lowered further at the end of 36 months compared with at the end of 12 months （P〈0.05）. CONCLUSION： Significant reduction in BP and LVMI was achieved in hypertensive patients treated with HCTZ combined spironolactone, and the curative efficacy increased time - dependently.

关 键 词：高血压 左室肥厚 左室重量指数 

分 类 号：R972.4[医药卫生—药品] R969.4[医药卫生—药学]