淫羊霍苷对免疫增强作用的实验研究  

Experimental Study of Effect of Longspur epimedium Glycoside on Increasing Immunity Function

作　　者：崔新颖[1] 崔新羽[1] 张成义[1] 

机构地区：[1]北华大学药学院,吉林吉林132013

出　　处：《北华大学学报（自然科学版）》2008年第3期223-225,共3页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅资助项目(吉教科合字[2003]第21号)

摘　　要：目的观察淫羊霍苷对小鼠免疫器官、巨噬细胞吞噬功能及抗体生成的影响．方法本实验采用腹腔巨噬细胞功能测定法和免疫器官重量法及溶血素测定法，观察吞噬百分数、吞噬指数，取脾脏、胸腺称质量，计算脾指数、胸腺指数、溶血素的生成．结果淫羊霍苷能显著提高实验动物的脾、胸腺的质量，且小鼠的腹腔巨噬细胞数量及吞噬活性明显提高．随着剂量的增加，吞噬百分率、吞噬指数与对照组比明显增加，并可明显提高小鼠血清溶血素（抗体）的产生水平．结论淫羊霍苷对小鼠免疫器官和网状内皮系统吞噬功能有明显的激活和增强作用；可明显增加B淋巴细胞产生抗体的能力，增加机体的体液免疫功能．Objective To observe the influence of Longspur epimedium glycosid on mice immuno-organs, macrophage phagocytic function and antibody formation. Methods The experiment uses the assay method of abdominal cavity macrophage phagocytic function, weight method of immuno-organs and assay method of hemolysin. The phagocytose percentage, phagocytose index, weighing the spleen and thymus, counting spleen index, thymus index, hemolysin count are observed. Results Longspur epimedium glycoside can obviously improve mice spleen and thymus weight, abdominal cavity phagocytose count and phagocytose function, and can obviously improve hemolysin level. Conclusion Longspur epimedium glycoside can activate and strengthen the function of mice immuno-organs and macrophage phagocytic; can obviously strengthen B-lymphocytes produce antibody and body humoral immunity function.

关 键 词：淫羊霍苷 脾指数 胸腺指数 吞噬百分率 抗体 

分 类 号：P967[天文地球—自然地理学]