FS-1272滴眼液对糖性白内障大鼠晶状体抗氧化系统的影响  

Effects of FS-1272 Gutta on Anti-oxidative System in Lens of Rats with Cataract Induced by D-galactose

作　　者：郑洁珍[1] 周大兴[1] 彭少华[1] 朱晓燕[1] 顾静[1] 王晶[1] 

机构地区：[1]浙江中医药大学药学院,杭州310053

出　　处：《浙江中医药大学学报》2008年第1期44-45,共2页Journal of Zhejiang Chinese Medical University

基　　金：上海新药研究开发中心横向课题(No:65086)~~

摘　　要：[目的]探讨FS-1272滴眼液对大鼠D-半乳糖性白内障的作用机理。[方法]采用大鼠D-半乳糖性白内障模型,测定晶状体中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱苷肽过氧化酶(GSH-px)、丙二醛(MDA)含量。[结果]FS-1272滴眼液能提高SOD、CAT、GSH-px活性,同时降低MDA含量。[结论]FS-1272滴眼液可减轻晶状体氧化损伤程度,从而起到延缓白内障发生和发展的作用。[Objective]To discuss mechanism of FS-1272 eye drops on cataract of rats induced by D-galactose. [Method]By using the model of cataract of rats induced by D-galactose to determine the content of SOD, CAT, GSH-px, MDA in lens. [Result] FS-1272 eye drops can increase the activities of SOD,CAT,GSH-px and decrease the content of MDA. [Conclusion]FS-1272 eye drops have the effect of delaying the generation and development of cataract by alleviating the extent of oxidative injury of lens.

关 键 词：白内障 D-半乳糖 超氧化物歧化酶 过氧化氢酶 丙二醛 谷胱苷肽过氧化酶 

分 类 号：R285.6[医药卫生—中药学]