双(α-呋喃甲酸)氧钒与六味地黄丸联合应用对糖尿病大鼠减毒增效作用的实验观察  

Effect of Combined Double Oxygen-Vanadium(α-Furoic Acid) and Liuwei Rehmaniae Bolus on Attenuation and Synergistic Effect in Rats with Diabetes Mellitus

作　　者：杨琳[1] 冯莉[1] 卢斌[1] 徐倩[1] 张柏丽[1] 范英昌[1] 

机构地区：[1]天津中医药大学,300193

出　　处：《天津中医药大学学报》2008年第2期78-80,共3页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：天津市高等学校科技发展基金项目(20050306);天津市卫生局中医中西医结合科研课题(07011)

摘　　要：[目的]观察双(α-呋喃甲酸)氧钒(VO-FA)与六味地黄丸联合使用对糖尿病大鼠减毒增效的作用。[方法]造模成功后,分别给予单一剂量的VO-FA及VO-FA联合六味地黄丸治疗,并设立正常组及模型组作对照。每周监测血糖,并在末次给药后检测其瞬时血糖的变化情况,4周后,检测血脂以及血清T-SOD、MDA值。[结果]VO-FA联合六味地黄丸组从给药第1周就表现出明显的降糖效果(P<0.01),每周降糖数值均低于单纯VO-FA组;还可降低糖尿病大鼠的总胆固醇水平(P<0.01),显著提高糖尿病大鼠的高密度脂蛋白水平(P<0.01),明显增强T-SOD的活性(P<0.01,P<0.05),并表现出降低丙二醛(MDA)的趋势。[结论]VO-FA与六味地黄丸联合使用对糖尿病大鼠有减毒增效的作用。[Objective] To observe the attenuation and synergistic effect of combined double Oxygen- Vanadium（α-Furoic Acid, VO-FA） and Liuwei Rehmaniae Bolus（LWRB） in rats with diabetes mellitus （DM）. [Method] The DM rats were given a single dose of VO-FA and combined VO-FA and Liuwei Rehmaniae Bolus respectively. Normal group and model group were also established. Blood-sugar was measured weekly and the transient blood sugar change after the last administration was determined. Four weeks later the blood-fat, serum T-SOD and MDA value were measured. [Result] The combined VO-FA and LWRB group may obviously decrease blood sugar and the total cholesterol level and enhance HDL level and T-SOD activity of DM rats（P〈0.01, P〈0.05）. There was a tendency to decrease MDA level. [Conclusion] The combined VO-FA and LWRB has obvious attenuation and synergistic effect in DM rats.

关 键 词：糖尿病 双(Α-呋喃甲酸)氧钒 六味地黄丸 减毒增效 实验研究 

分 类 号：R932[医药卫生—生药学]