Full-angle optical imaging of near-infrared fluorescent probes implanted in small animals  

作　　者：Gang Hu Junjie Yao Jing Bai 

机构地区：[1]Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China

出　　处：《Progress in Natural Science:Materials International》2008年第6期707-711,共5页自然科学进展·国际材料（英文版）

基　　金：the National Natural Science Foundation of China（Grant Nos.30670577,60571013, 60331010）;the National Basic Research Program of China（No.2006CB705700）;the Hi-Tech Research and Development Program of China（No.2006AA020803）.

摘　　要：To provide a valuable experimental platform for in vivo biomedical research of small animal model with fluorescence mediated approach,we developed a whole-body near-infrared fluorescence molecular imaging system as described in this paper.This system is based on a sensitive CCD camera and has the ability to achieve 360°full-angle source illuminations and projections capture of the targets to obtain the dense sampling by performing rotational scan.The measurement accuracy is validated from cylinder phantom experiments by the comparison between the experimental data and theoretical predictions.Finally,we also present typical in vivo images of fluores-cent tube implanted into the mouse body.The results are promising and have proved the system imaging performance for macroscopic optical biomedical research.To provide a valuable experimental platform for in vivo biomedical research of small animal model with fluorescence mediated approach, we developed a whole-body near-infrared fluorescence molecular imaging system as described in this paper. This system is based on a sensitive CCD camera and has the ability to achieve 360~ full-angle source illuminations and projections capture of the targets to obtain the dense sampling by performing rotational scan. The measurement accuracy is validated from cylinder phantom experiments by the comparison between the experimental data and theoretical predictions. Finally, we also present typical in vivo images of fluorescent tube implanted into the mouse body. The results are promising and have proved the system imaging performance for macroscopic optical biomedical research.

关 键 词：Fluorescence molecular imaging Small animal imaging Fluorescent probe 

分 类 号：Q959[生物学—动物学]