SEREX技术在筛选疾病相关抗原中的应用  

Application of SEREX technique in screen of disease-associated antigens

作　　者：葛昆[1] 钟理[1,2] 吴策[1] 祖金池[3] 柳峰松[1] 王海霞(综述)[1] 

机构地区：[1]河北大学生命科学学院生物芯片研究室,河北保定071002 [2]City of Hope National Medical Center, Duarte, California, USA [3]河北大学附属医院胸外科,河北保定071000

出　　处：《免疫学杂志》2008年第4期479-482,共4页Immunological Journal

基　　金：动物性食品安全检测和癌症早期诊断蛋白芯片的研究(05245514D)

摘　　要：重组cDNA表达文库血清学分析(SEREX)方法是一种筛选疾病相关抗原的有效分析方法,其筛选鉴定的疾病抗原不仅可对疾病进行早期检测,还能作为免疫治疗的靶标。本综述从肿瘤和其它具有免疫原性的疾病方面介绍了SEREX技术的应用价值,在总结SEREX缺点的基础上提出了SEREX技术的改进方向。Serological analysis of recombinant cDNA expression library （SEREX） is a useful technique to screen disease-associated antigens. These disease-associated antigens can be used as disease markers for early diagnosis, and also as valuable targets for immunotherapy. This review summarizes broad applications of the SEREX technique in tumor and other autoimmunity diseases. It also reveals some limitations of this technique and discusses possible improvements for the future direction.

关 键 词：SEREX技术 cDNA噬菌体文库 肿瘤相关抗原 疾病相关抗原 

分 类 号：R392-33[医药卫生—免疫学]