抗滋养细胞膜抗体、人绒毛膜促性腺激素抗体与体外受精-胚胎移植结局的关系  

The correlation of antitrophoblast antibody and hCG antibody with IVF-ET outcome

作　　者：邹淑花[1] 宋东坡[1] 张鹏[1] 丛雪[1] 李波[1] 吴瑞英[1] 

机构地区：[1]青岛市妇女儿童医疗保健中心,青岛266011

出　　处：《生殖医学杂志》2008年第3期175-177,共3页Journal of Reproductive Medicine

摘　　要：目的探讨抗滋养细胞膜抗体(ATA)、人绒毛膜促性腺激素(hCG)抗体对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法选择2002年1月至2007年7月在本生殖医学中心由于不明原因性不育、女方输卵管因素和(或)男方轻度少弱精子症因素不育而接受IVF-ET治疗的妇女140例,其中持续妊娠妇女65例作为对照组,反复种植失败31例、生化妊娠丢失26例及临床妊娠丢失18例妇女作为研究组。比较研究组和对照妇女各不育因素所占比例;血清ATA、抗hCG抗体阳性率。结果研究组中不明原因性不育明显高于对照组(P<0.01);研究组ATA阳性率显著高于对照组(P<0.01);研究组中生化妊娠组和临床妊娠丢失组hCG抗体阳性率无显著性差异(P>0.05),但显著高于对照组和反复种植失败组(P>0.05)。结论自身免疫异常所致的ATA可干扰整个妊娠过程,hCG抗体的存在能增加IVF-ET临床妊娠流产率和生化妊娠流产率。Objectives： To analyze the effect of antitrophoblast antibody （ATA） and hCG antibody （hCG-Ab） on in vitro fertilization and embryo transfer （IVF-ET） outcome. Methods. One hundred and forty women with infertility due to immune disorders, salpingemphraxis or/and male factor who underwent IVF-ET in Qingdao Reproductive Center were included in this study. 65 women who achieved clinical pregnancy and continued to at least 13 weeks of gestation comprised the control group. 75 women with previous IVF-ET failure （26 women with biochemical pregnancy loss, 18 with clinical pregnancy loss and 31 with repeated implantation failure） comprised the study group. We distinguished the causes of infertility and compared the positive rate of ATA and hCG-Ab between the two groups. Results： The rate of immune disorders was higher in study group than in control group （P〈0.01）. The positive rate of ATA in study group was higher than that in control group （P〈0. 01）. hCG-Ab showed no difference between the clinical pregnancy loss people and biochemical pregnancy people （P〉 0.05）, but both higher than that in the control group and repeated implantation people （P〈0. 05）. Conclusions; ATA and The existence of ATA could hCG-Ab would over-express in the infertile patients with immune disorders. affect the whole pregnancy process, while hCG-Ab may be one of the reasons for the increased pregnancy loss.

关 键 词：体外受精-胚胎移殖 妊娠结局 抗滋养细胞膜抗体 人绒毛膜促性腺激素抗体 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]