急性混合型高脂血症对急性心肌梗死面积的影响及其机制探讨  

Effects of acute mixed hyperlipidemia on acute myocardial infarction size and its mechanism

作　　者：陈红[1] 汪若婕[1] 任景怡[1] 武蓓[1] 李丽君[1] 

机构地区：[1]北京大学人民医院心内科,北京100044

出　　处：《北京大学学报（医学版）》2008年第3期258-261,共4页Journal of Peking University:Health Sciences

摘　　要：目的:探讨急性混合型高脂血症对急性心肌梗死面积的影响及机制。方法:将53只Sprague-Dawley(SD)大鼠分为3组:对照组(n=15)静脉注射0.9%(质量分数)生理盐水1.0 mL,低剂量组(n=17)和高剂量组(n=21)分别静脉注射10%(质量分数)Triton WR-1339溶液0.5 mL和1.0 mL。给药24 h后建立急性心肌梗死模型。测定给药前、给药24 h血脂水平和血清脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)的活性,并观察急性心肌梗死24 h后各组大鼠心肌梗死面积。结果:与给药前相比,低剂量组血浆总胆固醇(total cholesterol,TC)和甘油三酯(triglycerides,TG)浓度[分别为(6.92±1.48)mmol/L和(11.76±2.76)mmol/L]均明显升高(P<0.01),高剂量组升高更为明显[分别为(11.91±0.87)mmol/L和(33.97±5.85)mmol/L]。两组血浆低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)浓度也较给药前升高(P<0.05),但血浆高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)浓度较给药前明显降低(P<0.01)。另外,给药24 h后3组SD大鼠的血清Lp-PLA2的活性组间比较以及与给药前相比差异均无统计学意义(P>0.05)。大鼠心肌梗死面积在低剂量组和高剂量组分别为(55.2±3.1)%和(51.4±8.3)%,两组间差异无统计学意义(P=0.336),但与对照组[(37.0±4.2)%]相比均明显增加(P<0.001)。结论:急性混合型高脂血症能增加大鼠急性心肌梗死面积,Lp-PLA2在该过程中的作用还有待进一步探讨。Objective：To investigate the effect of acute mixed hyperlipidemia on acute myocardial infarct size and the potential mechanism. Methods： Fifty-three Spragne-Dawley （SD） rats were divided into three groups ： the control group （n = 15 ） was injected with 1.0 mL 0. 9% sodium chloride, the low dose group （n = 17） and high dose group （n =21） were injected with 0. 5 mL and 1.0 mL 10% Triton WR-1339 solution respectively. Acute myocardial infarction was produced 24 hours after the injection. Serum lipid and the activity of lipoprotein-associated phospholipase A2 （ Lp-PLA2 ） were measured before and 24 hours after the injection. Rats were killed 24 hours after ligation and their hearts were excised to evaluate the myocardial infarct size. Results： Serum total cholesterol （TC） and triglycerides （TG） concentrations were （6. 92 ± 1.48） mmol/L and （ 11.76 ± 2.76） mmol/L in the low dose group 24 hours after injection, （11.91±0. 87） mmol/L and （33.97 ±5.85） mmol/L in the high dose group, and both increased significantly compared with the baseline. Also serum low density lipoprotein cholesterol （LDL- C） concentration increased （ P 〈 0. 05 ） in the two groups, but high density lipoprotein cholesterol （ HDL- C） had an obvious decrease （P 〈0. 01 ）. And 24 hours after injection, the activity of Lp-PLA2 in the control group, low dose group and high dose group did not differ compared either with the baseline or among them （P 〉 0. 05 ）. Myocardial infarct size was significantly （ P 〈 0. 001 ） larger in the low dose group compared with the control group [ （55.2 ± 3.1 ） % vs （ 37.0 ± 4. 2） %, respectively, P 〈 0. 001 ], so was in the high dose group [ （51.4 ± 8.3 ） % vs （ 37.0 ± 4. 2） %, respectively, P 〈 0. 001 ], but it did not differ between the two groups（P = 0. 31 ）. Conclusion： Acute mixed hyperlipidemia could increase acute myocardial infarct size. The role of lipoprotein-associated phospho-lipase A2 in it was not

关 键 词：高脂蛋白血症V型 心肌梗死 磷脂酶A 

分 类 号：R589.2[医药卫生—内分泌]