紫癜性肾炎患儿血浆血栓素A2前列环素水平及其比值的变化  

Plasma thromboxane A_2 and prostaglandin I_2 levels and their ratio in children with Henoch-Schonlein purpura nephritis

作　　者：吕学云[1] 杨焕云 杨巧芝[1] 梁珺[1] 朱艳萍[1] 董胜英[1] 孙文英[1] 

机构地区：[1]聊城市人民医院儿科,山东聊城252000 [2]聊城市中医院检验科,山东聊城252000

出　　处：《中国当代儿科杂志》2008年第3期343-345,共3页Chinese Journal of Contemporary Pediatrics

基　　金：聊城市2007年科技攻关项目

摘　　要：目的探讨紫癜性肾炎(HSPN)患儿急性期和恢复期血浆血栓素A2(TXA2)、前列环素(PGI2)的水平及其比值变化的临床意义。方法采用双抗体夹心酶联免疫吸附(ELISA)法检测45例HSPN患儿急性期、恢复期及20例健康儿童血浆血栓素TXA2和PGI2水平并观察TXA2/PGI2比值的变化。结果HSPN患儿急性期TXA2水平明显高于对照组,PGI2水平明显低于对照组,TXA2/PGI2比值明显高于对照组(P<0.01);恢复期TXA2水平仍明显高于对照组(P<0.05),PGI2水平回升,且高于正常,TXA2/PGI2比值降至正常。结论HSPN患儿急性期存在TXA2/PGI2平衡失调,TXA2/PGI2比值明显升高,它可能通过多种途径参与肾小球损伤的发生、发展。恢复期TXA/PGI比值降至正常。两者的单个变化并不重要,其比值相对平衡对HSPN患儿的康复更为重要。Objective To study the changes and roles of plasma thromboxane A2 （ TXA2 ） and prostaglandin 12 （PGT2 ） levels and their ratio in Henoch-Schonlein purpura nephritis （HSPN） in children. Methods Plasma levels of TXA2 and PGI2 were measured using ELISA in 45 children with HSPN and 20 healthy children. Results Plasma TXA2 level was significantly higher, while plasma PGI2 level was significantly lower in HSPN children in the acute phase than in the control （ P 〈 0.01 ）. The ratio of TXA2/PGI2 in HSPN children in the acute phase was statistically higher than in the control （9.55 ±3.56 vs 0.87 ±0.21; P 〈0.01 ）. In the convalescence phase, plasma TXA2 level remained higher and plasma PGI2 level was elevated and higher than in the control, so the ratio of TXA2/PGI2 was reduced to normal level. Conclusions The imbalance of TXA2 and PGI2 may be involved in the development of renal damage in children with HSPN. The balance of TXA2 and PGI2 contributes to renal recovery.

关 键 词：紫癜性肾炎 血栓素A2 前列环素 儿童 

分 类 号：R726.9[医药卫生—儿科]