ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学分析  

Pathological characterization of the chronic hepatitis B with ALT less than 2×ULN/L

作　　者：李静[1] 刘素芬[1] 叶立红[1] 杜瑞清[1] 卢建华[1] 来家琪[1] 

机构地区：[1]石家庄市第五医院,河北石家庄050021

出　　处：《临床肝胆病杂志》2008年第3期189-190,共2页Journal of Clinical Hepatology

摘　　要：目的观察ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学与ALT的相关性。方法选择符合诊断标准的303例慢性乙型肝炎患者,检测血清肝功能、进行肝脏活检,肝脏组织标本进行常规病理检测。结果ALT小于2×ULN慢性乙型肝炎患者肝组织64.68%有2级以上的炎症改变,56.44%有2期以上的纤维化。本组中ALT男性均值为(39.73±19.14)U/L,女性为(29.21±13.90)U/L。结论ALT与炎性分级、纤维化分期均有相关性。ALT正常与不正常的慢性乙型肝炎患者肝脏组织炎性分级、纤维化分期不同,随着ALT数值的升高肝组织炎症及纤维化改变越明显。Objective To analyze the relationships between alanine aminotransferase （ALT） and hepatic histopathology in chronic hepatitis B（CHB） patients with ALT2 × ULN/L. Methods 303 patients with the diagnosis of CHB, the liver functions were tested and the pathological changes were shown by liver biopsy. Results The inflammatory grade was at 2 stage or higher in 64. 68% of patients and the hepatic fibrosis degree were at 2 stage and higher in 56. 44% of patients. The relationship between ALT and inflammatory grade/fibrotic stage was positive correlation. Conclusion There were differences of inflammatory grade/fibrotic stage between patients with normal ALT and patients with abnormal ALT. The inflammatory and fibrosis in liver progressed along with the increasing of ALT.

关 键 词：乙型肝炎 丙氨酸氨基转移酶 肝组织病理 

分 类 号：R512.6[医药卫生—内科学]