Th1/Th2细胞失衡与急性冠脉综合征  

Significance of Th1 and Th2 function imbalance in patients with acute coronary syndrome

作　　者：罗小雨[1] 陈建昌[1] 洪小苏[1] 冯萍[1] 

机构地区：[1]苏州大学附属第二医院心脏病科,215004

出　　处：《江苏医药》2008年第6期547-548,共2页Jiangsu Medical Journal

摘　　要：目的探讨急性冠脉综合征(ACS)患者外周血辅助性T细胞(Th)1和2功能失衡及其意义。方法85例患者中急性心肌梗死(AMI)组21例、不稳定性心绞痛(UA)组22例、稳定性心绞痛(SA)组19例、胸痛综合征(CPS)组23例,所有患者均经冠状动脉造影证实,酶联免疫吸附法测定超敏C反应蛋白(hsCRP),流式细胞术检测Th1、Th2。结果AMI、UA组hsCRP和Th1水平增高;Th2水平各组间无显著区别;hsCRP与Th1水平呈正相关。结论ACS患者存在Th1/Th2失衡,表现为Th1功能亢进,可能参与ACS的发病过程。Objective To study the significance of Thl/Th2 function imbalance in patients with acute coronary syndxome（ACS）. Methods Eighty-five patients were categorized into four groups of 21 patients with acute myocardial infarction （group AMI）, 22 patients with unstable angina （ group UA）, 19 patients with stable angina（group SA） and 23 patients with chest pain syndrome（group CPS）. All patients were diagnosed by coronary angiography. ELISA was used to measure the level of high sensitive C reactive protein （hsCRP）. Thl and Th2 were measured in the peripheral blood using flow cytometric analysis. Results The level of hsCRP in group AMI and UA was obviously higher than that of group SA and CPS （P〈0. 05）. The level of Th1 in group AMI and UA was higher than that in group SA and CPS （P〈0. 01）, while the level of Th2 showed no difference among the four groups （P〉0. 05）. The level of Th1 was positively correlated with that of hsCRP. Conclusion The Th1/Th2 functional imbalance exists in patients with ACS. The up-regulation of Thl cell function may be one of the mechanisms for developing ACS.

关 键 词：急性冠脉综合征 T辅助细胞 超敏C反应蛋白 

分 类 号：R541[医药卫生—心血管疾病]