豚鼠到大鼠异种心脏移植模型的改进  

An improvement of animal model for cardiac xenotransplantation from cavys to rats

作　　者：仲宁[1] 沈振亚[1] 叶文学[1] 胡江文[1] 丁琦[1] 闫效坤[1] 张胜超[1] 

机构地区：[1]苏州大学附属第一医院心血管外科,215006

出　　处：《江苏医药》2008年第6期594-595,共2页Jiangsu Medical Journal

基　　金：国家自然科学基金资助项目(39993430)

摘　　要：目的探讨豚鼠到大鼠异种腹腔心脏移植模型建立的技巧。方法改进了供受体的麻醉、供心的摘取、受体腹腔血管的准备、心肌保护及血管吻合技术,建立66例豚鼠到大鼠异种腹腔心脏移植模型。结果豚鼠到大鼠异种腹腔心脏移植的成功率达90.91%,缩短了手术时间。结论通过技术的提高,提高了豚鼠到大鼠异种心脏移植的成功率。Objective To improve the technique of establishing animal model for abdominal heterotopic cardiac xenotransplantation from cavys to rats. Methods Sixty-six animal models of heterotopic cardiac xenotransplantation from cavys to rats were established by improving the anesthesia management, donor cardiectomy, preparation of celiac vessel, myocardial protection and microsurglcal technique of vascular anastomosis. Results The success rate of abdominal heterotopic cardiac xenotransplantation from cavys to rats was 90. 91%. Conclusion The success rate of establishing animal models for abdominal heterotopic cardiac xenotransplantation from cavys to rats can be increased by improving the conventional technique.

关 键 词：异种心脏移植 动物模型 豚鼠 大鼠 

分 类 号：R654[医药卫生—外科学]