白萝卜提取物促胃动力作用中Cajal间质细胞与P物质的变化  

Kinetogenic effects of raphanus sativus l extract on Cajal and SP changes in gastrointestinal tract

作　　者：黄裕新[1] 王伟[1] 夏德雨[1] 颜云龙[1] 冯国华[1] 王景杰[1] 

机构地区：[1]第四军医大学唐都医院消化科,陕西西安710038

出　　处：《胃肠病学和肝病学杂志》2008年第6期467-469,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：陕西省科技攻关课题[2004K10-G4(1)]

摘　　要：目的探讨白萝卜提取物(raphanus sativus lextract,Ecr)通过Cajal间质细胞促胃肠动力作用机制。方法40只SD大鼠随机分为A(Ecr)组、B(0.9%氯化钠对照)组分别灌服等体积Ecr和0.9%氯化钠,1h后用双重免疫荧光组织化学标记的方法观察胃电起搏区Cajal间质细胞(interstitial cells of Cajal,ICC)与P物质(SP)阳性神经及产物表达的变化。结果肌间神经丛中ICC与SP阳性神经呈网络样分布,二者紧密毗邻;肌间神经丛及肌层内与ICC结合的SP阳性神经产物表达明显增加(P<0.01)。结论白萝卜提取物的促胃肠动力作用可能与胃体ICC上结合的SP阳性神经产物表达增高有密切关系。Objective To study the mechanisms of Raphanus sativus 1 extract（Ecr）. Methods Forty SD rats were randomly divided into A（Ecr） group and B（control）group. Ecr or 0.9% Nacl were given respectively. The distributions of SP and Cajal in gastric body investigated by double immunofluorescin histochemistry method 1 h later. Results The expressions of SP on Cajal increased significantly （P〈0.01 ） in gastric body of rats at 1 h after Ecr given. Conclusion The kinetogenic effect of Ecr is closely correlated to the increase of SP on Cajal expression.

关 键 词：白萝卜提取物 CAJAL间质细胞 P物质 双重免疫荧光组织化学 

分 类 号：R333.2[医药卫生—人体生理学]