脱细胞异体真皮基质口腔黏膜补片治疗口腔黏膜缺损:随机对照  

Effect of acellular dermal matrix allograft to repair the defect of oral mucosa: Randomized control observation

作　　者：李英 杜志刚 

机构地区：[1]北京忠意齿科门诊部,北京市100021

出　　处：《中国组织工程研究与临床康复》2008年第19期3734-3735,共2页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30471893)~~

摘　　要：选取口腔黏膜缺损患者32例,按随机数字表法分为2组,脱细胞异体真皮基质修复组16例应用生物材料T-1型脱细胞异体真皮基质口腔黏膜组织补片,自体中厚皮片修复组16例。结果表明,中厚皮片移植后6个月时皮肤表面角质层变薄,颜色呈粉红色,但有别于黏膜色泽,触感仍较黏膜韧,大体观察不再有收缩;移植后1年冷热知觉开始逐渐恢复。脱细胞异体真皮移植后3个月移植区已完全变成黏膜色泽,视觉上很难区分移植区与正常黏膜区,触之较周围黏膜稍有韧感,患者有部分知觉恢复;移植后6个月时与周围黏膜融为一体,很难区分,并完全恢复冷热知觉,说明脱细胞异体真皮基质口腔黏膜组织补片具有良好的细胞生长诱导功能和生物相容性。Thirty-two patients with oral mucosa defect were divided into two groups according to a random number table. In group A, 16 cases of oral mucosa defect were repaired by autodermic blair graft, and group B using T-1 biomaterial acellular dermal matrix allograft. Results revealed that, the surface corneum of the skins repaired by autodermic blair graft became thin, and was colored as pink, which were different from mucosa and felt more tenacious 6 months after operation, without the presence of contraction; One year after operation, the cold and hot perception began to recover. In the acellular dermal matrix allograft group, the graft area was difficultly distinguished from the normal mucosa with the identical color, and touched tenaciously, partial recovery of perception was observed at 3 months; the allograft converged with the surrounding mucosa, the cold and hot perception was completely recovered at 6 months, indicating the acellular dermal matrix allograft is a new method to repair the defect of oral mucosa, with the good induction capacities of cellular growth and biocompatibility.

关 键 词：生物材料 口腔黏膜 移植 中厚皮片 脱细胞真皮基质 

分 类 号：R318[医药卫生—生物医学工程]