碳纳米管在修饰酶传感器中的应用(英文)  

Application of carbon nanotubes in modified oxidase biosensors

作　　者：赵文秀[1] 董宏博[1] 张伟萍[1] 崔桂花[1] 

机构地区：[1]吉林医药学院化学教研室,吉林省吉林市132013

出　　处：《中国组织工程研究与临床康复》2008年第19期3793-3795,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：碳纳米管是一种新兴的纳米材料,碳纳米管良好的电子传递能力使其可用于修饰电极,可以降低化学物质氧化还原反应的过电位,改善生物分子氧化还原可逆性;其大比表面积有利于酶的固定化,还能促进酶活性中心与电极表面的电子传递;功能化的碳纳米管还能与各种生物分子键合将其固定于电极表面。随着制备和纯化工艺的改进,碳纳米管将为生物传感器的发展开创更广阔的前景。本文总结和分析碳纳米管在生物传感器中的应用、研究现状和发展趋势。综述了吸附型、糊类、原位生长(阵列)型和共价键合型等几种类型碳纳米管修饰酶传感器及在DNA生物传感器中的应用,并对各种传感器的制备、特点和研究现状进行了述评。Carbon nanotubes are a novel kind of nano-materials, and contribute to modify electrodes using their good capacity of electric transmission. Furthermore, carbon nanotubes may reduce the overpotential caused by the oxidation-reduction reaction of chemical materials, and ameliorate the oxidation-reduction reversibility of the biomolecules; Their Wide specific surface area leads to enzyme immobilization and promote the electric transmission between enzyme active center and electrode surface; Functionalized carbon nanotubes bonding with various biomolecules will benefit to fix these biomolecules on the electrode surface. With the development of preparation and purification techniques, carbon nanotubes may widen the prospect of biosensors applied. The aim of this paper is to summarize and analyze the application, research status and development tendency of carbon nanotubes with regard to biosensors. Moreover, this paper reviews various carbon nanotubes modified oxidase biosensors, such as adsorption, paste, array and covalent bond, together with their application on DNA biosensor. The preparation, characteristics and research status of various sensors are also summarized.

关 键 词：碳纳米管 修饰电极 生物传感器 综述文献 

分 类 号：R318.08[医药卫生—生物医学工程]