对乙酰氨基酚直肠给药用于小儿术后镇痛的临床观察  

Clinical Study of the Efficiency and Safty of Pediatric Postoperative Pain Control with Acetaminophen Viarectum

作　　者：钟颖[1] 衡新华[1] 杨文燕[1] 毕春[1] 陈同延[2] 

机构地区：[1]昆明医学院第一附属医院麻醉科,云南昆明650031 [2]麻省总医院麻醉科

出　　处：《昆明医学院学报》2008年第3期137-139,共3页Journal of Kunming Medical College

摘　　要：目的观察对乙酰氨基酚直肠给药用于小儿术后镇痛的疗效.方法60例拟行腹部疝修补术的患儿,采用七氟醚复合异丙酚气管插管全身麻醉,随机分为两组.对乙酰氨基酚组在气管插管后经直肠给对乙酰氨基酚,曲马多组在术后经骶管注射曲马多行术后镇痛;记录给药后1h、4h、6h、8h、12h及24h的各项指标,通过疼痛评分及出现的副作用评价镇痛效果.结果两组患儿镇痛效果组间比较差异无统计学意义(P>0.05),对乙酰氨基酚的副作用小于曲马多.结论对乙酰氨基酚直肠给药用于小儿腹部疝修补术的术后镇痛安全有效,副作用少.Objective To evaluate the analgesic effect and safety of pediatric postoperative pain control with Acetaminophen via rectum. Methods Sixty patients undergoing surgical treatments of hemiorrhaphy with Sevoflurane and Propofol general anesthesia were randomly divided into two groups： group A received acetaminophen via rectum as postoperative pain control before surgery started and group B received sacral spinal analgesia with tramadol after operation. After acetaminophen was placed and tramadol was given, pain scores, global impression score and side effects were assessed at 1 h, 4 h, 6 h, 8 h, 12 h and 24 h. Results There was no difference in pain scores and global impression score between the two groups （P 〉 0.05）. Group B caused more adverse effects than Group A （ P 〈 0.01）. There were no any changes both in GroupAnd Group B. Conclusion The result indicate that using effective, safe and simple method to control postoperative pain in children. in hepatic and coagulation function acetaminophen via rectum is an effective, safe and simple method to control postoperative pain in children.

关 键 词：对乙酰氨基酚 小儿 术后镇痛 直肠给药 

分 类 号：R614[医药卫生—麻醉学]