瓦松提取物对实验性胃溃疡的治疗作用  

Effects of fimbriate orostachys herb extractive on experimental gastrohelcoma animals

作　　者：李杰[1] 崔淑香[1] 周玲[1] 王芃[1] 牟艳玲[1] 

机构地区：[1]山东省医学科学院药物研究所药理室

出　　处：《中国临床药理学与治疗学》2008年第4期388-391,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：山东省优秀中青年科学家科研奖励基金(9924)

摘　　要：目的:观察瓦松提取物对实验性胃溃疡的治疗作用。方法:以Wistar大鼠和昆明种小鼠为研究对象,复制5种实验性胃溃疡动物模型(小鼠束缚水浸应激致胃溃疡模型、吲哚美辛致小鼠胃溃疡模型、乙醇致大鼠胃溃疡模型、乙酸致大鼠胃溃疡模型和大鼠幽门结扎致胃溃疡模型)。将大鼠随机分为瓦松提取物400、200、100mg/kg剂量组、阳性对照组和模型对照组;小鼠随机分成瓦松提取物800、400、200mg/kg剂量组、阳性对照组和模型对照组。测定胃溃疡指数、胃液游离酸排出量及总酸排出量。结果:瓦松提取物400、800mg/kg剂量组能降低小鼠应激性溃疡溃疡指数(P<0.05);200～800mg/kg瓦松提取物对吲哚美辛致小鼠胃溃疡溃疡指数有明显的降低作用(P<0.05或P<0.01);同时对乙醇引起的大鼠胃溃疡也具有明显的抑制作用(P<0.05),并可明显促进乙酸致大鼠胃溃疡溃疡的愈合,但对动物胃液分泌及胃蛋白酶活性无明显影响。结论:瓦松提取物对实验性胃溃疡有明显的预防和治疗作用。AIM： To investigate the antiulcer effects of fimbriate orostachys herb extractive on experimental gastrohelcoma animals. METHODS： Five kinds of animal models with experimental gastric ulcer were established and gastric mucosal injuries were induced by applying indomethac or imposing stress in mice, applying ethanol or acetic acid or pyloric ligation in rats, respectively. The rats were divided into experimental groups treated with fimbriate orostachys herb extractive 400, 200, 100 mg/kg, positive control group, and model control group. The mice were divided into experimental groups treated with fimbriate orostachys herb extractive 800,400, 200 mg/kg, positive control group, and model group. The gastric ulcer index, gastric juice free acid output, total acid output were measured in animals. RESULTS： Administration with fimbriate orostachys herb extractive 400 and 800 mg/kg were able to reduce the ulcer index of rats with stress ulceration（ P 〈 0.05）, and 200 - 800 mg/kg doses of fimbriate orostachys herb extractive were able to reduce the ulcer index of mice with gastroheleoma induced by indomethac （ P 〈0.05 or P 〈 0.01）and rats with gastrohelcoma induced by ethanol （P 〈 0.05 ）, meanwhile, the gastric ulcer healing in gastrohelcoma rats accused by acetic acid was promoted obviously, but there was no significant influence on gastric secretion and pepsase. CONCLUSION： Fimbriate orostachys herb extractive has evident preventive and therapeutical effects on experimental gastrohelcoma animals.

关 键 词：瓦松提取物 胃溃疡 大鼠 小鼠 

分 类 号：R965.1[医药卫生—药理学]