视黄醇结合蛋白4遗传多态性与2型糖尿病的关系  

Relationship between type 2 diabetes and retinol binding protein 4 and its genetic polymorphism

作　　者：周芳[1] 周宏灏[1] 刘昭前[1] 

机构地区：[1]中南大学临床药理研究所,遗传药理学湖南省重点实验室

出　　处：《中国临床药理学与治疗学》2008年第4期452-456,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(30572230);教育部新世纪优秀人才支持计划(NCET-04-0749)

摘　　要：视黄醇结合蛋白(retinol binding protein,RBP)属于视黄醇运载蛋白,其血清水平常作为临床营养状况、肝肾疾病的早期诊断和疗效的评价指标。最新研究发现:视黄醇结合蛋白4(RBP4)为一种新的脂肪源性信使,参与了胰岛素抵抗和2型糖尿病的发生。这一发现使得RBP4开始倍受关注。本文主要介绍视RBP4的结构、遗传多态性及其与2型糖尿病之间的最新研究进展。Retinol-binding protein （RBP） is the primary transport protein for retionl. Senan plasma levels of RBP can serve as an index for detecting the development and the curative effects of the diseases of kindey and liver, as well as nutritional diseases. Recent research reported that retinol binding protein 4 （RBP4） is a newly discovered messenger from adipocyte, which plays a role in insulin resistance and obesity. The research and findings of the structure, gene polymorphism of RBP4, and association of RBP4 with type 2 diabetes （T2DM） was reviewed in this article.

关 键 词：视黄醇结合蛋白4 单核苷酸多态性 2型糖尿病 

分 类 号：R589[医药卫生—内分泌]